HMS Plus Hemostasis Management System

When measuring the ACT is not enough

The HMS Plus Hemostasis Management System is a reliable and versatile platform used to perform multiple tests for heparin management. By providing information regarding the individual patient's response to heparin, the HMS Plus System determines the appropriate dose for the patient so that the needed anticoagulant and antithrombotic effect can be achieved.

During cardiopulmonary bypass, the minimum standard of care is to measure the activated clotting time (ACT). Measuring the ACT, or the degree of anticoagulation, is not always an indication of adequate heparinization or whether an appropriate antithrombotic state has been achieved. The effects of many variables including medications, heparin anticoagulation, temperature and dilution can affect the ACT.

Why is Hemostasis Management important for your patients?

• Assist in prevention of thrombus formation
• Help preserve clotting factors
• Monitor multiple aspects of anticoagulation

Benefits of Improved Hemostasis Management

• Fewer complications associated with excessive blood loss 1
• Preservation of the coagulation system, resulting in fewer transfusions 2
• Fewer surgical reoperations 3 , thus decreasing associated costs

Optimized patient treatment using the HMS Plus System includes the following tests:

HEPARIN DOSE RESPONSE (HDR)

Assessing patient's individual response to heparin

• Documents individual patient response to heparin, identifies resistant/sensitive patients
• Indicates when standard protocol is appropriate, thereby minimizing heparin over- and under-dosing, and identifies heparin requirements to achieve a desired activated clotting time, thus linking a quantitative measurement with a functional test

HEPARIN ASSAY CARTRIDGES (HPT)

Measuring actual circulating heparin concentration

• Allows maintenance of desired heparin level and calculates protamine reversal dosage requirements to avoid protamine overdose
• Confirms complete reversal and identifies post surgical heparin rebound

HIGH RANGE ACT (HR-ACT)

Measures heparin effect

• Establishes patient's baseline clotting time
• Monitors overall anticoagulant effect prior to, during, and after cardiopulmonary bypass

Ease of Use

• The HMS Plus System dispenses the appropriate volume of blood or control material into each cartridge well
• Easy storage and retrieval of results
• Bar Code Scanner (optional) saves time by making entry of cartridge and control lot numbers and expiration dates as well as user and patient ID easier to enter

Data and QC Management

• Supports the latest requirements for POC testing equipment
• Stores up to 200 patient and 100 QC records
• QC and user lockout options
• Purge function of all test records
• Connectivity ready

Quality Control

• Lyophilized controls are available to verify instrument and cartridge function and to meet regulatory guidelines for testing.
• The HEPtrac™ Electronic Quality Control provides a multi-level testing in one device

External Data Manager (EDM)

• Stand alone software
• Easier download of data
• Documentation for billing and reimbursement
• QC and patient data management including preformatted reports

1. Hill, AG, et al. More precise heparin and protamine management during cardiopulmonary bypass. Proceedings of the American Academy of Cardiovascular Perfusion. 1990;12-16.

2. Despotis, GJ, et al. More effective suppression of hemostasis system activation in patients undergoing cardiac surgery by heparin dosing based on heparin blood concentrations rather than ACT. Thromb Haemost. 1996;67:2-8.

3. Despotis, GJ, et al. The impact of heparin concentration and activated clotting time monitoring on blood conservation. J Thorac Cardiovascular Surg. 1995;110:46-54.

4. Bowie, JE, et al. Automated management of heparin anticoagulation in cardiovascular surgery. Proceedings of the American Academy of Cardiovascular Perfusion. 1985;6:1-5