Prevent Excessive Hemodilution

Habib RH, Zacharias A, Schwann TA, Riordan CJ, Durham SJ, Shah A. Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: Should current practice be changed? J Thorac Cardiovasc Surg 2003;125(6):1438-50.¹⁴
Abstract

DeFoe GR, Ross CS, Olmstead EM, Surgenor SD, Fillinger MP, Groom RC, Forest RJ, Pieroni JW, Warren CS, Bogosian ME, Krumholz CF, Clark C, Clough RA, Weldner PW, Lahey SJ, Leavitt BJ, Marrin CA, Charlesworth DC, Marshall P, O'Connor GT. Lowest hematocrit on bypass and adverse outcomes associated with coronary artery bypass grafting. Northern New England Cardiovascular Disease Study Group. Ann Thorac Surg 2001;71(3):769-76.¹⁵
Abstract

Shapira OM, Aldea GS, Treanor PR, Chartrand RM, DeAndrade KM, Lazar HL, Shemin RJ. Reduction of allogeneic blood transfusions after open heart operations by lowering cardiopulmonary bypass prime volume. Ann Thorac Surg 1998;65(3):724-30.¹⁶
Abstract

Prevent Emboli

Hammon JW, Stump DA, Kon ND, Cordell AR, Hudspeth AS, Oaks TE, Brooker RF, Rogers AT, Hilbawi R, Coker LH, Troost MD. Risk factors and solutions for the development of neurobehavioral changes after coronary artery bypass grafting. Ann Thorac Surg 1997;63:1613-8.¹⁷
Abstract

Clark RE, Brillman J, Davis DA, Lovell MR, Price TR, Magovern GJ. Microemboli during coronary artery bypass grafting. Genesis and effect on outcome. J Thorac Cardiovasc Surg 1995;109(2):249-57.¹⁸
Abstract

Pugsley W, Klinger L, Paschalis C, Treasure T, Harrison M, Newman S. The impact of microemboli during cardiopulmonary bypass on neuropsychological functioning. Stroke 1994;25(7):1393-9.¹⁹
Abstract

Avoid Direct Reinfusion of Cardiotomy Suction Blood

Weerwind PW, Lindhout T, Caberg NE, De Jong DS.Thrombin generation during cardiopulmonary bypass: the possible role of retransfusion of blood aspirated from the surgical field. Thromb J 2003;1(1):3.²⁰
Abstract

Aldea GS, Soltow LO, Chandler WL, Triggs CM, Vocelka CR, Crockett GI, Shin YT, Curtis WE, Verrier ED. Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits. J Thorac Cardiovasc Surg 2002;123:742-55.²¹
Abstract

Brooker RF, Brown WR, Moody DM, Hammon JW Jr, Reboussin DM, Deal DD, Ghazi-Birry HS, Stump DA. Cardiotomy suction: a major source of brain lipid emboli during cardiopulmonary bypass. Ann Thorac Surg 1998;65(6):1651-5.²²
Abstract

Provide Precise, Patient-Specific Hemostasis Management

Koster A, Fischer T, Praus M, Haberzettl H, Kuebler WM, Hetzer R, Kuppe H. Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management. Anesthesiology 2002;97(4):837-41.²³
Abstract

Shigeta O, Kojima H, Hiramatsu Y, Jikuya T, Terada Y, Atsumi N, Sakakibara Y, Nagasawa T, Mitsui T. Low-dose protamine based on heparin-protamine titration method reduces platelet dysfunction after cardiopulmonary bypass. J Thorac Cardiovasc Surg 1999; 118(2):354-360.²⁴
Abstract

Despotis GJ, Joist JH, Hogue CW Jr, Alsoufiev A, Kater K, Goodnough LT, Santoro SA, Spitznagel E, Rosenblum M, Lappas DG. The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg 1995;110(1):46-54.²⁵
Abstract

Provide a Heparin Biocompatible Surface

Svenmarker S, Haggmark S, Jansson E, Lindholm M, Appelblad M, Sandstrom E, Abert T. Use of heparin-bonded circuits in cardiopulmonary bypass improves clinical outcome. Scand Cardiovasc J 2002;35:241-246.²⁶
Abstract

Heyer EJ, Lee KS, Manspeizer HE, Mongero L, Spanier TB, Caliste X, Esrig B, Smith C. Heparin-bonded cardiopulmonary bypass circuits reduce cognitive dysfunction. J Cardiothorac Vasc Anesth 2002;16(1):37-42.²⁷
Abstract

Kopp R, Mottaghy K, Kirschfink M. Mechanism of complement activation during extracorporeal blood-biomaterial interaction: effects of heparin coated and uncoated surfaces. ASAIO Journal 2002;48:598-605.²⁸
Abstract

Mahoney CB, Lemole GM. Transfusion after coronary artery bypass surgery: the impact of heparin-bonded circuits. Eur J CardioThorac Surg 1999;16:206-210.²⁹
Abstract

Mahoney CB. Heparin-bonded circuits: clinical outcomes and costs. Perfusion 1998;13:192-204.³⁰
Abstract

Aldea GS, Doursounian M, O'Gara P, Treanor P, Shapira OM, Lazar HL, Shemin RJ. Heparin-bonded circuits with a reduced anticoagulation protocol in primary CABG: a prospective, randomized study. Ann Thorac Surg 1996:62:410-8.³¹
Abstract

Avoid Air-Blood Interfaces

Brown Mahoney C, Donnelly JE. Impact of closed versus open venous reservoirs on patient outcomes in isolated coronary artery bypass surgery. Perfusion 2000;15:467-472.³²
Abstract

Schonberger JP, Everts PA, Hoffmann JJ. Systemic blood activation with open and closed reservoirs. Ann Thorac Surg 1995;59:1549-55.³³
Abstract

Minimize Circuit Surface Area

Gourlay T, Samartzis I, Taylor KM. The effect of haemodilution on blood-biomaterial contact-mediated CD11b expression on neutrophils: ex vivo studies. Perfusion 2003;18(2):87-93.³⁴
Abstract

Gourlay T, Stefanou DC, Asimakopoulos G, Taylor KM. The effect of circuit surface area on CD11b(mac-1) expression in a rat recirculation model. Artif Organs 2001;25(6):475-9.³⁵
Abstract

Minimize Sheer, Stasis, Turbulence

Kawahito S, Maeda T, Yoshikawa M, Takano T, Nonaka K, Linneweber J, Mikami M, Motomura T, Ichikawa S, Glueck J, Nose Y. Blood trauma induced by clinically accepted oxygenators. ASAIO J 2001;47(5):492-5.³⁶
Abstract

Goodin MS, Thor EJ, Haworth WS. Use of computational fluid dynamics in the design of the Avecor Affinity oxygenator. Perfusion 1994;9(3):217-22.³⁷
Abstract