The Clinical Standard in Regional Oximetry

The INVOS™ system is the only cerebral/somatic oximetry system with FDA cleared improved outcome claims.([FOOTNOTE=Murkin JM, Adams SJ, Novick RJ, et al. Monitoring brain oxygen saturation during coronary bypass surgery: a randomized, prospective study. Anesth Analg. 2007;104(1):51-58.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=284535]),([FOOTNOTE=Casati A, Fanelli G, Pietropaoli P, et al. Continuous monitoring of cerebral oxygen saturation in elderly patients undergoing major abdominal surgery minimizes brain exposure to potential hypoxia. Anesth Analg. 2005;101(3):740-747.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=143155]),([FOOTNOTE=FDA 510(k) K082327 REF: 886-11-PM-0256BRC],[ANCHOR=],[LINK=])

The INVOS™ system provides real-time monitoring of changes in regional oxygen saturation (rSO2) of blood in the brain or other body tissues beneath the sensor for effective oxygen monitoring in adults, children, infants and neonates.

This unique system allows clinicians to measure site-specific oxygen levels rather than requiring them to infer the data from systemic, whole body measures such as blood pressure and pulse oximetry. Available in two or four data channels, clinicians can conveniently monitor multiple brain and body areas.

INVOS™ 5100C Cerebral/Somatic Oximeter Features

  • Monitors the stability of cerebral and peripheral circulations in a noninvasive, real-time way
  • Leverages associations between cerebral and peripheral circulations to better manage care; i.e. whether the periphery appears to be shunting blood flow to preserve the brain
  • Helps clinicians determine whether vascular beds surrounding vital organ areas are adequately perfused
  • Helps clinicians more closely identify and manage regional oxygenation issues in the O.R., PICU, NICU and/or cardiac catheter lab
  • Helps clinicians obtain objective data noninvasively for decision making
  • Intended for patients of any age or weight; with tailored sensors for adults, children, infants and neonates



Available with either two or four data channels.

Two-channel (standard option) comes with:

  • Two-channel INVOSTM 5100C cerebral/somatic oximeter - Preamplifier with cable
  • Channel 1 and 2 (model 5100C-PA)
  • Reusable sensor cable: Channel 1 (Model RSC-1)
  • Reusable sensor cable: Channel 2 (model RSC-2)
  • USB flash drive (model 5100C-USB)
  • Power cord

Four-channel includes all of the above and the following must be ordered:

  • Preamplifier (model5100C-PB)
  • Reusable sensor cable: Channel 3 (model RSC-3)
  • Reusable sensor cable: Channel 4 (model RSC-4)

Reflects Site-Specific Tissue Perfusion Noninvasively

INVOS™ system technology gives you a noninvasive “window” to the body’s microvasculature; a direct and dynamic site of gas exchange that transports about half the body’s blood volume. Measuring blood oxygenation in the microvasculature results in sensitive and site-specific insights on perfusion adequacy or – with multi-sensor monitoring – perfusion distribution across the brain and body.

Unlike parameters that measure only venous or arterial blood, INVOS™ technology includes contributions from both in a 3:1 ratio, yielding a venous-weighted percent saturation. This provides real-time data about the balance or imbalance of oxygen supply and demand, thus reflecting venous oxygen reserve - the oxygen remaining after extraction by tissues and vital organs. Decreases in venous oxygen reserve can be a warning of developing pathology and deteriorating patient condition. Published adult data has shown that an rSO2 of 50 or a 20% decline from baseline are cause for concern and intervention, and an rSO2 of 40 or a 25% decline from baseline are associated with neurologic dysfunction and other adverse outcomes.([FOOTNOTE=Edmonds HL, Jr Ganzel BL, Austin EH 3rd. Cerebral oximetry for cardiac and vascular surgery. Semin Cardiothorac Vasc Anesth. 2004;8(2):147-166.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=297413]),([FOOTNOTE=Alexander HC, Kronenefeld MA, Dance GR. Reduced postoperative length of stay may result from using cerebral oximetry monitoring to guide treatment. Ann Thorac Surg. 2002;73:373-C.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=573245]),([FOOTNOTE=Cho H, Nemoto EM, Yonas H, Balzer J, Sclabassi RJ. Cerebral monitoring by means of oximetry and somatosensory evoked potentials during carotid endarterectomy. J Neurosurg. 1998;89(4):533-538. ],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=297313]),([FOOTNOTE=Iglesias I, Murkin JM, Bainbridge D, Adams S. Monitoring oxygen saturation significantly decreases postoperative length of stay: a prospective randomised blinded study. Heart Surg Forum. 2003;6:204.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=573311]),([FOOTNOTE=Edmonds HL Jr, Singer I, Sehic A, Strickland TJ. Multimodality neuromonitoring for neurocardiology. J Interv Cardiol. 1998;11(3):197-204.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=805129]),([FOOTNOTE=Yao FSF, Tseng CC, Woo D, Huang SW, Levin SK. Maintaining cerebral oxygen saturation during cardiac surgery decreased neurological complications. Anesthesiology. 2001;95:A152.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=573402]),([FOOTNOTE=Roberts KW, Crnkowic AP, Linnerman IJ. Near infrared spectroscopy detects critical cerebral hypoxia during carotid endarterectomy in awake patients. Anesthesiology. 1998;89(3A):A934.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=805131]),([FOOTNOTE=Higami T, Kozawa S, Asada T, et al. Retrograde cerebral perfusion versus selective cerebral perfusion as evaluated by cerebral oxygen saturation during aortic arch reconstruction.Ann Thorac Surg. 1999;67(4):1091-1096.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=214004]),([FOOTNOTE=Singer I, Dawn B, Edmonds Jr. H, Stickland TJ. Syncope is predicted by neuromonitoring in patients with ICDs. PACE. 1999;22(1):216-222.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=297319])

The INVOS™ system utilizes near-infrared light at wavelengths that are absorbed by hemoglobin (730 and 810 nm). Light travels from the sensor’s light emitting diode to either a proximal or distal detector, permitting separate data processing of shallow and deep optical signals. INVOS™ system’s ability to localize the area of measurement, called spatial resolution, has been empirically validated in human subjects.([FOOTNOTE=Hongo K, Kobayashi S, Okudera H, Hokama M, Nakagawa F. Noninvasive cerebral optical spectroscopy. Depth-resolved measurements of cerebral haemodynamics using indocyanine green. Neurol Res. 1995;17(2):89-93.],[ANCHOR=View Abstract],[LINK=/content/covidien/websites/medtronic/com/en/covidien/support/clinical-evidence.html?id=297292]) Data from the scalp and surface tissue are subtracted and suppressed, reflecting rSO2 in deeper tissues. This same concept applies to somatic monitoring.

The result is continuous, real-time adequacy of perfusion data in up to four sites of your choice.

INVOS™ Cerebral/Somatic Oximetry System Support Center

The INVOS support center promotes the successful operation of the INVOS™ cerebral/somatic oximetry system. Access all the resources you need for ongoing support and use of your INVOS™ system from application videos to in-service and procedural user guides.





Technology Overview of the INVOS™ Cerebral/Somatic Oximetry System

Explore the INVOS™ system advantages and how it improves patient outcomes.

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Learn How the INVOS™ System Works

The INVOS™ system is designed to help treat a range of complex patients, download this info sheet to learn how the system works.

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INVOS™ Cerebral/Somatic Oximetry for Adults Product Brochure

Learn more about the INVOS™ system and how it improves patient outcomes and safety in adult surgery.

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INVOS™ Cerebral/Somatic Oximetry for Neonates Product Brochure

Learn how INVOS™ technology is playing a role in early detection of ischemic threats to the brain and vital organs in the NICU.

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Cerebral Desaturation is Common, Costly and Debilitating Infographic

An end organ function infographic that provides information on the impact of cerebral desaturation.

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INVOS™ Cerebral/Somatic Oximetry Analytics Tool Brochure

A brochure that describes the INVOS™ analytics tool features and functionality.

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Complimentary INVOS™ Monitoring System Analytics Tool

Learn about this complimentary, interactive resource that facilitates evaluation of regional oxygenation (rSO2) case data.

Analytics Tool

INVOS™ Cerebral/Somatic Oximeter Analytics Tool User Guide

A user guide that provides information and installation instructions for the INVOS™ analytics tool.

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Detection and Correction of Brain Oxygen Imbalance. Surgical and Critical Care Applications of the INVOS™ Cerebral Oximeter

A clinician pocket guide for the detection and correction of brain oxygen imbalance using the INVOS™ cerebral oximeter.

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Interactive Carotid Endarterectomy Clinical Evidence Guide

An INVOS™ cerebral/somatic oximetry clinical evidence guide for carotid endarterectomy procedures.

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Minimally Invasive Cardiac Surgery Clinical Evidence Guide

A review of the evidence detailing the use of the INVOS™ system during minimally invasive cardiac surgery procedures.

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INVOS™ Cerebral Perfusion in Cardiac Surgery Evidence Guide

A review of the evidence detailing the use of the INVOS™ system during cardiac surgery to help improve outcomes and increase patient safety.

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INVOS™ System Case Study of a Coronary Artery Bypass Graft Procedure

Learn how the INVOS™ system facilitates timely intraoperative intervention to maintain adequate cerebral oxygen saturation and improve clinical outcomes.

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INVOS™ Cerebral/Somatic Oximetry Clinical Evidence Bibliography – Cardiac Surgery

Over 330 clinical studies that identify the applications and benefits of INVOS™ cerebral/somatic oximetry technology during cardiac surgery.

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