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Activa® Therapy

Activa Parkinson’s Control Therapy Bibliography

Note that the articles listed in these bibliographies may include information about an Activa System device or a use of brain stimulation that has not been approved by the U.S. Food and Drug Administration.

General Information

The Deep-Brain Stimulation for Parkinson’s Disease Study Group. Deep-Brain Stimulation of the Subthalamic Nucleus or the Pars Interna of the Globus Pallidus in Parkinson’s Disease. N Engl J Med. 2001;345:956-963.

Deuschl G, et al. Deep Brain Stimulation for Parkinson’s Disease. Journal of Neurology. 2002: 249(Suppl 3), III/36-III/39.

Limousin P, et al. Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease. N Engl J Med. 1998: 339(16), 1105-1111.

Pollak P, et al. Treatment Results: Parkinson’s Disease. Mov Disord. 2002; 17 (Suppl 3): S75-83.

Starr P, et al. Deep Brain Stimulation for Movement Disorders. Neurosurgery Clinics of North America. 1998: 9(2): 381-402.

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Safety and Efficacy

Ostergaard K, et al. Effects of Bilateral Stimulation of the STN in Patients with Severe Parkinson’s Disease and Motor Fluctuations. Mov Disord. 2002: 17, 693-700.

Simuni T, et al. Bilateral Stimulation Of The Subthalamic Nucleus in Patients with Parkinson Disease: A Study Of Efficacy And Safety. J Neurosurg. 2002: 96(4), 666-672.

Thobois S, et al. Subthalamic Nucleus Stimulation in Parkinson’s Disease. J Neuro 2002: 249, 529-534.

Vesper J, et al. Results of Chronic Subthalamic Nucleus Stimulation for Parkinson’s Disease: A 1-Year Follow-Up Study. Surg Neurol 2002: 75, 306-313.

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Long Term Follow-Up

Benabid AL, et al. Long Term Electrical Inhibition of Deep Brain Targets in Movement Disorders. Mov Disorders 1998: 13 (Supp 3), 119-125.

Lyons K, et al. Long-Term Efficacy Of Globus Pallidus Stimulation For The Treatment Of Parkinson's Disease. Stereotactic and Functional Neurosurgery 2003: 79: 214-220.

Pahwa R, et al. Bilateral Subthalamic Stimulation In Patients With Parkinson Disease: Long-Term Follow Up. J Neurosurg 2003: 99(1) 71-77.

Tavella A, et al. Deep brain stimulation of the Subthalamic Nucleus in Parkinson’s Disease: Long-Term Follow-up. Neurological Sciences 2002: 23 (Supp 2), S111-112.

Valldeoriola F, et al. Bilateral Subthalamic Stimulation Monotherapy In Advanced Parkinson's Disease: Long-Term Follow-Up of Patients. Mov Disorders 2002: 17, 125-132.

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Neuropsychiatric Outcomes

Ardouin C, et al. Bilateral Subthalamic or Pallidal Stimulation for Parkinson’s Disease Affects Neither Memory nor Executive Functions: A Consecutive Series of 62 Patients. Ann Neurol. 1999: 46, 217-223.

Daniele A, et al. Cognitive and Behavioral Effects of Chronic Stimulation of the STN in Patients with Parkinson’s Disease. J Neurol Neurosurg Psychiatry 2003: 74, 175-182.

Pillon B, et al. Neuropsychological Changes between “Off” and “On” STN or GPi Stimulation in Parkinson’s Disease. Neurology 2000: 55, 411-418.

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Patient Selection

Lang A, et al. Deep Brain Stimulation for Parkinson’s Disease: Patient Selection and Evaluation. Mov Disord. 2002: 17(Supp 3), S94-101.

Lopiano L, et al. Deep Brain Stimulation of the Subthalamic Nucleus in PD: An Analysis of the Exclusion Causes. Journal of the Neurological Sciences. 2002: 195, 167-170.

Pillon B. Neuropsychological Assessment for Management of Patients with Deep Brain Stimulation. Mov Disord 2002: 17(Supp 3), S116-122.

Saint-Cyr J, et al. Neuropsychological Assessment of Patients for Movement Disorder Surgery. Mov Disord 2000: 15, 771-783.

Welter M, et al. Clinical Predictive Factors of Subthalamic Stimulation of Parkinson’s Disease. Brain 2002: 125, 575-583.

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Patient Management

Krack P. et al. Postoperative Management of Subthalamic Nucleus Stimulation for Parkinson’s Disease. Mov Disord. 2002: 17(Supp 3), S188-197.

Kumar R. Methods for Programming and Patient Management with Deep Brain Stimulation of the Globus Pallidus for the Treatment of Advanced Parkinson’s Disease and Dystonia. Mov Disord 2002: 17(Supp 3) S198-207.

Moro E, et al. The Impact of Parkinson’s Disease of Electrical Parameter Settings in STN Stimulation. Neurology 2002: 59, 706-713.

Volkman J, et al. Introduction to the Programming of Deep Brain Stimulators. Mov Disord 2002: 17(Supp 3), S181-187.

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Intraoperative Technique

Benazzouz A. Intraoperative Microrecordings of the Subthalamic Nucleus in Parkinson’s Disease. Mov Disord 2002: 17(Supp 3), S145-149.

Lozano A, et al. Microelectrode Recordings in the Pallidum. Mov Disord 2002: 17(Supp 3), S150-154.

Pollak P, et al. Intraoperative Micro- and Macrostimulation of the Subthalamic Nucleus in Parkinson’s Disease. Mov Disord 2002: 17(Supp 3), S155-161.

Starr P. Placement of Deep Brain Stimulators into the Subthalamic Nucleus or Globus pallidus internus: Technical Approach. Stereotact Funct Neurosurg 2003; 79:118-145.

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Postoperative Technique

Hamel W, et al. Deep brain stimulation of the subthalamic nucleus in Parkinson’s disease: evaluation of active electrode contacts. J Neurol Neurosurg Psychiatry 2003; 74, 1036-1046.

Saint-Cyr J, et al. Localization of Clinically Effective Stimulating Electrodes in the Human Subthalamic Nucleus on MRI. J Neurosurg 2002; 97,1152-1166.

Starr P, Chadwick C, Theodosopoulos P, Lindsey N, Byrd D, Mosley A, Marks W. Implantation of deep brain stimulators into the subthalamic nucleus: Technical approach and magnetic resonance imaging-verified lead locations. J Neurosurg. 2002;97:370-387.

Yelnik J, et al. Localization of stimulating electrodes in patients with Parkinson disease by using a three-dimensional atlas-magnetic resonance imaging coregistration method. J Neurosurg 2003;99:89-99.

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Additional Information

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