Canadian Trial of Physiologic Pacing

Progression to chronic atrial fibrillation after pacing: The Canadian Trial of Physiologic Pacing

Skanes AC, Krahn AD, Yee R, et al, for the CTOPP Investigators.
J Am Coll Cardiol. 2001;38:167-172.

2,568 patients from the Canadian Trial Of Physiologic Pacing (CTOPP), a multicenter, prospective, randomized study, were implanted with a ventricular-based or a physiologic pacing system. Physiologic pacing reduced the annual rate of development of chronic AF in these patients undergoing first pacemaker implants. Age > 74 years, SA node disease, and prior AF predicted the development of chronic AF. Patients with structurally normal hearts appeared to derive greatest benefits.

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