DAVID Trial

Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator. The dual chamber and VVI implantable defibrillator (DAVID) trial

Wilkoff BL, Cook JR, Epstein AE, et al, for the DAVID Trial Investigators.
JAMA. 2002;288:3115-3123.

506 patients with indications for ICD therapy were enrolled in this multicenter, randomized clinical trial. All patients had an ICD with dual-chamber, rate-responsive pacing capability implanted, which was randomly programmed to ventricular backup pacing (VVI) or dual-chamber rate-responsive pacing (DDDR). For patients with standard indications for ICD therapy, no indication for cardiac pacing, and LVEF of < 40%, dual-chamber pacing offered no clinical advantage over ventricular backup pacing and may be detrimental by increasing the combined end-point of death or hospitalization for heart failure.

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