Study Conclusions

The implantation of a cardiac resynchronization therapy (CRT) device should be routinely considered as an adjunct to optimal medical therapy for patients with moderate to severe heart failure due to left ventricular systolic dysfunction and cardiac dyssynchrony because it

• Reduced risk of all-cause mortality
• Reduced risk of all-cause mortality cardiovascular or unplanned hospitalization
• Reduced risk of all-cause mortality or unplanned heart failure hospitalization

These benefits are in addition to previously established outcomes of CRT, including improved cardiac structure and function, symptoms, and quality of life (QoL).^5,7-13