Medtronic
 
 

Heart Failure

Clinical Benefits of CRT

A number of randomized, controlled clinical studies have demonstrated that CRT has a number of positive clinical effects, including:

  • Reduction in left ventricular end-diastolic volume and diameter1,3,4 [graph]
  • Improvement in cardiac function and structure 1-3 [graph]
  • Improvement in quality of life and functional capacity1-3,5 [graph]
  • Improvement in exercise capacity1-3,5 [graph]
  • Reduction in heart failure hospitalization6
  • Reduction in mortality (CRT-D) from progressive heart failure6
References
  1. St. John Sutton MG, Plappert T, Abraham WT, et al. Effect of cardiac resynchronization on left ventricular size and function in chronic heart failure. Circulation 2003; 107:1985 -1990.
  2. Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, Wilkoff B, Canby RC, Schroeder JS, Liem LB, Hall S, Wheelan K for The Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE ICD) Trial Investigators.Combined cardiac resynchronization and implantable cardioverter defibrillation in advanced chronic heart failure. The MIRACLE ICD Trial. JAMA 2003; 289:2685-2694
  3. Higgins SL, Hummel JD, Niazi IK, Giudici MC, Worley SJ, Saxon LA, Boehmer JP, Higginbotham MJ, DE Marco T, Foster E, Yong, PG. Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias J Am Coll Cardiol 2003; 42:1454-1459. 
  4. Yu CM, Chau E, Sanderson JE, Fan K, Tang MO, Fung WH, Lin H, Kong SL, Lam YM, Hill MRS, Lau CP. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation 2002;105:438-445.
  5. Cazeau S, Leclercq C, Lavergne T, et al. Effects of Multisite Biventricular Pacing in Patients With Heart Failure and Intraventricular Conduction Delay. N Engl J Med. 2001;344:873-80
  6. Bradley D, Bradley E, Baughman K, et al. Cardiac resynchronization and death from progressive heart failure: A meta-analysis of randomized controlled trials. JAMA 2003; 289:730-740.

Additional Information