Medtronic
 
 

Heart Failure

Treating Ventricular Dyssynchrony
with CRT

Resynchronization Therapy procedure
[+] Click to enlarge

Cardiac Resynchronization Therapy provides atrial-synchronized, biventricular pacing using standard pacing technology combined with a special third lead that is implanted via the coronary sinus and positioned in a cardiac vein to sense and/or pace the left ventricle. Following a sensed atrial contraction or atrial-paced event, both ventricles are stimulated to synchronize their contraction. The resulting ventricular resynchronization reduces mitral regurgitation and optimizes left ventricular filling, thereby improving cardiac function.1-10

 

References
  1. Kerwin WF, Botvinick EH, O'Connell JW, et al. Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. J Am Coll Cardiol 2000; 35(5): 1221-1227.
  2. Le Rest C, Couturier O, Turzo A, et al. Use of left ventricular pacing in heart failure: evaluation by gated blood pool imaging. J Nucl Cardiol 1999;6:651-656.
  3. Saxon LA, Kerwin WF, Cahalan MK, et al. Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function. J Cardiovasc Electrophysiol 1998; 9(1): 13-21.
  4. Kass D, Chen-Huan C, Curry C, Talbot M, Berger R, Fetics B, Nevo E. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 1999;99:1567-1573.
  5. Walker S, Levy T, Rex s, et al. Left Ventricular Remodelling with Chronic Bi-Ventricular Pacing. Europace 2000; I (suppl D): abstract 212/5.
  6. Porciani MC, Puglisi A, Colella A, et al. Echocardiographic Evaluation of the Effect of Biventricular Pacing: The InSync Italian Registry. Eur Heart J Supplements. 2000;2(Suppl J):J23-J30.
  7. Auricchio A, Stellbrink C, Block M, Sack S, Vogt J, Bakker P, Klein H for the Pacing Therapies for Congestive Heart Failure Study Group; Kramer A, Ding J, Salo R, Tockman B, Pochet T, Spinelli J, for the Guidant Congestive Heart Failure Research Group. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. Circulation 1999;99:2993-3001
  8. Nishimura RA, Hayes DL, Holmes DR Jr, Tajik AJ. Mechanism of hemodynamic improvement by dual-chamber pacing for severe left ventricular dysfunction: an acute Doppler and catheterization hemodynamic study. J Am Coll Cardiol 1995; 25 (2): 281-8.
  9. Brecker SJ, Xiao HB, Sparrow J, Gibson DG. Effects of dual-chamber pacing with short atrioventricular delay in dilated cardiomyopathy. Lancet 1992; 340 (8831): 1308-12.
  10. Leclercz C, Alanso C, Pavin D. Comparative Effects of Ventricular Resynchronization Therapy in Patients With LV Systolic Dysfunction of Idiopathic or Ischemic Origin. J Am Coll Cardiol 2001. Feb; 37 (2 Suppl A): 154A.

Additional Information