Medtronic
 
 

Insertable
Cardiac Monitor

International Study on Syncope of Uncertain Etiology 2 (ISSUE 2)1

Objective

ISSUE 2 evaluated the effectiveness of a new strategy utilizing early application of an Insertable Loop Recorder (ILR) to select therapy and reduce syncope recurrence in patients with suspected neurally mediated syncope.

  • Only ECG-documented episodes were used to determine therapy treatment
  • Therapy selection was independent of tilt table test results
  • Both syncope recurrence and burden were assessed

Results

The ILR mechanism-based diagnostic strategy for neurally mediated syncope patients provided specific and effective therapy – with an 80% relative reduction in the one-year syncope recurrence rate in patients who received ILR-based therapy. The dominate therapy was cardiac pacing as the result of a median asystolic pause of 11.5 seconds.

References
  1. Brignole M, Sutton R, Menozzi C, et al. Early application of an implantable loop recorder allows effective specific therapy in patients with recurrent suspected neurally mediated syncope. Eur Heart J. 2006;27:1085-1092.

 

 

Additional Information