EnTrust™ Dual Chamber ICD

Patient-Centered Therapy

that promotes natural cardiac function¹

EnTrust
Model D154ATG

• Shock Less^{2, 3}
• Pace Less*^{2, 4, 5}
• Complete Information^{1, 6}

EnTrust D154ATG¹
35J delivered
8 seconds BOL, 11 seconds ERI
7.7 years*
35cc**, 68g
Programmable Active Can^®

Shock Less^{2, 3}

Unique features to reduce appropriate and inappropriate shocks

[+] Click to enlarge

ATP During Charging to reduce appropriate shocks^{2, 3}

• Reduce 3 out of 4 shocks^{2, 3} with proven PainFREE programming, with no delay to definitive therapy.¹
• Exclusive Advancement -- Nominally ON¹

ATP During Charging automatically delivers ATP while the capacitor charges, offering PainFREE termination of Fast VTs in the VF Zone with No Delay to definitive therapy.¹

Medtronic PainFREE RX II clinical conclusion: "compared to shocks, empirical ATP for FVT is highly effective, equally safe, and improves patient quality of life. It prevents painful shocks without any clinical difference in episode duration, arrhythmic syncope, acceleration, or sudden death."³

Request information on Medtronic PainFREE Therapy Clinical Results and Programming Tips.

Accurate Detection to reduce inappropriate shocks¹

Enhanced PR Logic^® with NEW Sinus Tach Rule™

Clinically Proven Shock Reduction
PR Logic is the most utilized, clinically proven and published SVT discrimination algorithm available.^{7, 8, 9}

Now PR Logic has been enhanced with a new Sinus Tach Rule.^1,5

The new Sinus Tach Rule was developed to address the most common cause of inappropriate ICD shock therapies, with no compromise in VT/VF detection.¹
    • Sinus tachycardia with long PR Intervals
    • Sinus tachycardia with Far Field R-Wave Detection

The new Sinus Tach Rule rejects over 1/3 more SVTs compared to PR Logic*** with no user programming required.¹⁰

Simple and Automatic — Nominally ON¹
Automatically responds to the patient's unique rhythm with no need for complex programming.

Pace Less

With clinically proven MVP Mode^{2, 4, 5}
(Managed Ventricular Pacing mode)

[+] Click to enlarge

Clinical Need

A growing body of evidence suggests that chronic RV apical pacing is associated with a variety of detrimental effects in patients, especially those with intact or intermittent AV conduction.^11-14

• Increased risk of heart failure (HF) hospitalization and death
• Increased risk of atrial fibrillation (AF)

Clinically Proven Medtronic Solution^{1, 4, 5}

MVP Mode in the EnTrust Dual Chamber ICD promotes intrinsic conduction by reducing unnecessary right ventricular pacing.¹

Clinically proven to reduce right ventricular pacing to approximately 0.1% (median) for patients with intrinsic conduction.⁵

The MVP mode provides consistent atrial pacing support with MVP ON compared to MVP OFF (DDDR).^{1, 5}

Complete Information for More Efficient Patient Care^1,6

Total AT/AF Co-morbidity Management

EnTrust family of ICDs provides a suite of features for total AT/AF co-morbidity management, including diagnostics to detect when your patient develops AT/AF, and both termination and intervention therapies.

• Reactive ATP offers more opportunities to terminate long AT episodes.
• Patient activated cardioversion with the InCheck™ Patient Assistant
• Cardiac Compass^® Trends provides unique AF burden trending as well as V. rate during AT/AF (bpm)
• Atrial Preference Pacing (APP)
• Atrial Rate Stabilization (ARS)
• Post-Mode Switch Overdrive Pacing (PMOP)

I'd like to learn more about the EnTrust Single Chamber ICD.

* 7.7 years — Conditions: 50% atrial and 5% ventricular pacing in MVP Mode at 60 ppm, 3V, 0.4 ms, 500 ohms; pre-arrhythmia EGM storage off; biannual charges (a charge is a full energy therapy or capacitor formation)
8.2 years — Conditions: 50% atrial and 5% ventricular pacing in MVP Mode at 60 ppm, 2.5V, 0.4 ms, 900 ohms; pre-arrhythmia EGM storage off; biannual charges

** Volume with connector holes unplugged.

***GEM^®DR

References

1. Medtronic EnTrust™ ICD Reference Manual.
2. Medtronic EnTrust™ ICD Implant Manual.
3. Wathen MS, DeGroot PJ, Sweeney MO et al., for the PainFREE Rx II Investigators. Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: pacing fast ventricular tachycardia reduces shock therapies (PainFREE Rx II) trial results. Circulation. Oct 2004; 110: 2591 - 2596.
4. Sweeney M, Shea J, Fox V, et al. Randomized pilot study of a new atrial-based minimal ventricular pacing mode with dual chamber implantable cardioverter-defibrillators. Heart Rhythm. 2004;1:160-167.
5. Mueller M, Medtronic Marquis^® MVP Mode study, April 2004, data on file.
6. Medtronic Human Factors Report, 2003, data on file.
7. Willkoff B, Gillberg J, DeSouza C. The Enhanced PR Logic (trademark) dual chamber tachyarrhythmia detection algorithm: retrospective analysis of supraventricular tachycardia with long PR intervals. JACC Abstract #873-4, Feb. 2001.
8. Willkoff B, Kuhlkamo V, Kacet S, et.al. Critical analysis of dual chamber implantable cardioverter-defibrillator arrhythmia detection: results and technical considerations. Circulation. 2001;103:381-386.
9. Medtronic data on file.
10. Stadler RW. An adaptive interval-based algorithm for withholding ICD therapy during sinus tachycardia, PACE May 2003; Vol26 1189-1201.
11. Willkoff BL , Cook JR, Epstein AE, et al. Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With an Implantable Defibrillator: the Dual Chamber and VVI Implantable defibrillator (DAVID) Trial. JAMA. December 25, 2002; 288 (24): 3115-3123.
12. Sweeney MO, Hellkamp AS, Ellenbogen KA, et al. MOde Selection Trial Investigators. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003 Jun 17;107(23):2932-2937.
13. Connolly SJ, Kerr CR, Gent M, et al. Effects of physiologic pacing vs ventricular pacing on the risk of stroke & death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators. New Eng J of Medicine, May 11, 2000;342(19):1385-1391.
14. Anderson H, Nielsen J, Thomsen P et al. Long-term follow-up of patients from a randomized trial of atrial versus ventricular pacing for sick sinus syndrome. Lancet. October 25, 1997;350:1210-1216.

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