EnTrust™ Family of ICDs

Patient-Centered Therapy

that promotes natural cardiac function¹

• Shock Less ^2,3
• Pace Less*^2,4,5
• Complete Information^1,6

EnTrust D154ATG1 Dual Chamber ICD 35J delivered 8 seconds BOL, 11 seconds ERI 7.7 years** 35cc***, 68g Programmable Active Can®	EnTrust D154VRC1 Single Chamber ICD 35J delivered 8 seconds BOL, 11.8 seconds ERI 10.7 years**** 35cc, 68g Programmable Active Can®

* Entrust D154ATG Dual Chamber only
**7.7 years - Conditions: 50% atrial and 5% ventricular pacing in MVP Mode at 60 ppm, 3V, 0.4 ms, 500 ohms; pre-arrhythmia EGM storage off; biannual charges (a charge is a full energy therapy or capacitor formation)
8.2 years -   Conditions: 50% atrial and 5% ventricular pacing in MVP Mode at 60 ppm, 2.5V, 0.4 ms, 900 ohms; pre-arrhythmia EGM storage off; biannual charges
*** Volume with connector holes unplugged
**** 10.7 years - Conditions: 15% VVI at 60 ppm, 3V, 0.4 ms, 500 ohms; pre-arrhythmia EGM storage off; biannual charges 11 years - Conditions: 15% VVI at 60 ppm, 2.5 V, 0.4 ms, 900 ohms; pre-arrhythmia EGM storage off; biannual charges

References

1. Medtronic EnTrust™ ICD Reference Manual.
2. Medtronic EnTrust™ ICD Implant Manual.
3. Wathen MS, DeGroot PJ, Sweeney MO et al., for the PainFREE Rx II Investigators. Prospective randomized multicenter trial of empirical antitachycardia pacing versus shocks for spontaneous rapid ventricular tachycardia in patients with implantable cardioverter-defibrillators: pacing fast ventricular tachycardia reduces shock therapies (PainFREE Rx II) trial results. Circulation. Oct 2004; 110: 2591 - 2596.
4. Sweeney M, Shea J, Fox V, et al. Randomized pilot study of a new atrial-based minimal ventricular pacing mode with dual chamber implantable cardioverter-defibrillators. Heart Rhythm. 2004;1:160-167.
5. Mueller M, Medtronic Marquis^® MVP Mode study, April 2004, data on file.
6. Medtronic Human Factors Report, 2003, data on file.
7. Willkoff B, Gillberg J, DeSouza C. The Enhanced PR Logic (trademark) dual chamber tachyarrhythmia detection algorithm: retrospective analysis of supraventricular tachycardia with long PR intervals. JACC Abstract #873-4, Feb. 2001.
8. Willkoff B, Kuhlkamo V, Kacet S, et.al. Critical analysis of dual chamber implantable cardioverter-defibrillator arrhythmia detection: results and technical considerations. Circulation. 2001;103:381-386.
9. Medtronic data on file.
10. Stadler RW. An adaptive interval-based algorithm for withholding ICD therapy during sinus tachycardia, PACE May 2003; Vol26 1189-1201.
11. Willkoff BL , Cook JR, Epstein AE, et al. Dual-Chamber Pacing or Ventricular Backup Pacing in Patients With an Implantable Defibrillator: the Dual Chamber and VVI Implantable defibrillator (DAVID) Trial. JAMA. December 25, 2002; 288 (24): 3115-3123.
12. Sweeney MO, Hellkamp AS, Ellenbogen KA, et al. MOde Selection Trial Investigators. Adverse effect of ventricular pacing on heart failure and atrial fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node dysfunction. Circulation. 2003 Jun 17;107(23):2932-2937.
13. Connolly SJ, Kerr CR, Gent M, et al. Effects of physiologic pacing vs ventricular pacing on the risk of stroke & death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators. New Eng J of Medicine, May 11, 2000;342(19):1385-1391.
14. Anderson H, Nielsen J, Thomsen P et al. Long-term follow-up of patients from a randomized trial of atrial versus ventricular pacing for sick sinus syndrome. Lancet. October 25, 1997;350:1210-1216.

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