Clinical Outcomes Cardiac Ablation for Atrial Fibrillation

Consistent and predictable outcomes with arctic front advance cryoballoon

Consistent outcomes with cryoballoon

single center published studies

1-Year Cryoballoon clinical data
single center published studies

Arctic Front Advance™ Cryoballoon has demonstrated consistent outcomes among various centers.

single procedure graph

Arrhythmia monitoring methods and definition of procedure success
(Freedom from AF Only or AF/AT/AFL) varied between studies. 


Reproducible results with cryoballoon14

Among centers with varying annual ablation volume, Arctic Front Advance Cryoballoon resulted in more consistent outcomes compared to radiofrequency.

Radiofrequency ablation results
Cryoballoon ablation results

shorter, more consistent* procedure times with cryoballoon from the FIRE AND ICE Trial15

shorter procedure times table

* Standard deviations were smaller in the cryoballoon group for all three procedure time measures, indicating more consistent times with less variation from the mean.
† t-test
** Protocol required 30 min. waiting period after last application to assess PV isolation.


References

1

Di Giovanni, et al. One-Year Follow-Up After Single Procedure Cryoballoon Ablation: A Comparison Between the First and Second Generation Balloon. J Cardiovasc Electrophysiol. 2014; 25(8):834-9.

2

Fürnkranz, et al. Improved 1-Year Clinical Success Rate of Pulmonary Vein Isolation with the Second-Generation Cryoballoon in Patients with Paroxysmal Atrial Fibrillation. J Cardiovasc Electrophysiol. 2014; 25(8):840-4

3

Aryana, et al. Acute procedural and cryoballoon characteristics from cryoablation of atrial fibrillation using the first- and second-generation cryoballoon: a retrospective comparative study with follow-up outcomes. J Interv Card Electrophysiol. 2014;41(2):177-86.

4

Aytemir, et al. Safety and efficacy outcomes in patients undergoing pulmonary vein isolation with second-generation cryoballoon. Europace. 2015; 17(3):379-87.

5

Greiss, et al. The impact of left atrial surface area and the second generation cryoballoon on clinical outcome of atrial fibrillation cryoablation. Pacing Clin Electrophysiol. 2015; 38(7):815-24.

6

Metzner, et al. One-Year Clinical Outcome After Pulmonary Vein Isolation Using the Second-Generation 28-mm Cryoballoon. Circ Arrhythm Electrophysiol. 2014;7(2):288-292.

7

Chierchia, et al. Second-generation cryoballoon ablation for paroxysmal atrial fibrillation: 1-year follow-up. Europace. 2014;16(5):639-644.

8

Chierchia, et al. Impact on Clinical Outcome of Premature Interruption of Cryoenergy Delivery Due to Phrenic Nerve Palsy During Second Generation Cryoballoon Ablation for Paroxysmal Atrial Fibrillation. Journal of Cardiovascular Electrophysiology. September 2015; 26:950-955.

9

Kumar, et al. Adenosine testing after second-generation balloon devices (cryothermal and laser) mediated pulmonary vein ablation for atrial fibrillation. J Interv Card Electrophysiol. 2014; 41(1):91-97.

10

Jourda, et al. Contact-force guided radiofrequency vs. second-generation balloon cryotherapy for pulmonary vein isolation in patients with paroxysmal atrial fibrillation-a prospective evaluation. Europace. 2015; 17(2):225-31.

11

Ciconte, et al. Single 3-minute freeze for second-generation cryoballoon ablation: one-year follow-up after pulmonary vein isolation. Heart Rhythm. 2015; 12(4):673-80.

12

Tebbenjohanns, et al. Shortening of freezing cycles provides equal outcome to standard ablation procedure using second-generation 28 mm cryoballoon after 15-month follow-up. Europace. 2016; 18(2):206-10.

13

Wissner, et al. One-year clinical success of a 'no-bonus' freeze protocol using the second-generation 28 mm cryoballoon for pulmonary vein isolation. Europace. 2015; 17(8):1236-40.

14

Providencia, et al. Cryoballoon or radiofrequency ablation for atrial fibrillation. New England Journal of Medicine. 2016; 375(11):1099.

15

Kuck, et al. Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2016; 374(23): 2235-45.