CLINICAL EVIDENCE—FLOW DIVERSION BRAIN ANEURYSM THERAPIES

PUFs trial

PUFs (Pipeline™ Embolization Device for Uncoilable or Failed Aneurysms) was a multicenter, prospective, interventional, single-arm trial to evaluate the safety and effectiveness of the Pipeline implant* in the treatment of complex intracranial aneurysms.

PUFs studied 108 patients with a wide-necked, large, or giant intracranial aneurysm in the petrous, cavernous, or paraophthalmic regions of the internal carotid artery.

  • For treatment success, target aneurysm had to be 100% occluded.
  • PUFs included a cohort of aneurysms that were challenging to treat, including giant and fusiform aneurysms (18.2 mm average size).

5-Year Results

0% RECURRENCE, 0% COMPLICATIONS, 95% COMPLETE OCCLUSION

CONCLUSION

Treatment of large and giant saccular and fusiform aneurysms in the internal carotid artery (ICA) with the Pipeline™ device is safe and highly effective.

PUFs Efficacy and Safety Outcomes

*

The PUFs study only included the Pipeline embolization device. The Pipeline Flex embolization device contains the same implant as the Pipeline embolization device.

Results may vary. Not all patients receive the same results.


1

Becske T. et al., Five-Year Results of the Pipeline for Uncoilable or Failed Aneurysms Trial. Neurosurgery (JNS). Published online Jan. 06, 2017.