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Questions and Answers – Infuse Bone Graft and LT Cage Device

Lumbar Degenerative Disc Disease

What is Infuse® Bone Graft and how does it compare to the natural protein in my body that helps bones to grow?

Infuse Bone Graft consists of two parts: a protein that is found in everyone’s body, plus a natural carrier for delivery. The protein ingredient in Infuse Bone Graft is rhBMP-2 (recombinant (engineered) human bone morphogenetic protein-2), a genetically engineered version of a protein everyone’s body produces naturally in small amounts to regulate bone growth and healing.

The natural carrier is a sponge manufactured from bovine (cow) Type 1 collagen. It releases the protein over time where it is placed, provides a scaffold (framework) for new bone to grow into, and is absorbed and replaced by bone.

Using Infuse Bone Graft eliminates the need for a second surgery to harvest, or remove surgically, bone from your body (“autogenous” bone) for placement at the surgery site. Autogenous bone harvest has the risk of pain, complications, longer surgical time, and more anesthesia.

Infuse Bone Graft eliminates the need for the harvest surgery, avoiding the pain associated with the bone harvest procedure.

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How does Infuse Bone Graft work?

Infuse Bone Graft is surgically placed where new bone growth is needed. It attracts your body’s own bone-building cells to the site and over time, new bone is formed. Bone grows where the Infuse Bone Graft is placed, for predictable bone growth results.

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What keeps this product from growing bone in other places in my body?

Infuse Bone Graft will stimulate bone formation under specific circumstances, and only when present at a certain concentration. These criteria will only be met at the site of surgery where the Infuse Bone Graft/LT-Cage® Device is implanted. Bone formation remote from the site of implantation was not seen in the clinical trials.

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If my doctor uses the Infuse Bone Graft/LT-Cage Device, will I get as strong of a fusion as if he used a bone graft from my hip?

Yes. Infuse Bone Graft should result in a fusion that is similar to what would have been formed if a patient’s own bone graft was used inside an LT-Cage Device.

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I have heard people talk about hip pain after harvesting lasting up to 2 years or longer. Is that true?

One of the disadvantages of taking bone from the hip is local pain at the harvesting site. This pain can sometimes be significant. Most often, it is temporary and resolves during the spinal recovery period. Occasionally, the pain may be more chronic. With Infuse Bone Graft and the LT-Cage Device, patients can avoid the need to have bone harvested for a spinal fusion.

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Information on this site should not be used as a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.