Mosaic Tissue Valve Heart Valve Disease


Mosaic Tissue Valve

Mosaic Tissue Valve

The Mosaic Bioprosthesis is obtained from the heart of a pig. A pig's heart anatomy is similar to that of a human heart. The leaflets that control the flow of blood in the Mosaic tissue valve are secured to a flexible frame (stent) for support. The stent is covered with a fine fabric, used to sew the valve into the heart.


The Mosaic valve is used to replace a damaged aortic valve or a damaged mitral valve, depending on your disease condition.


The Mosaic tissue valve provides you with the latest in advanced technology. This technology includes two tissue technologies: the AOA™ (alpha amino oleic acid) treatment and the Physiologic Fixation process.* Studies have shown that the Physiologic Fixation process helps preserve the structure and function found in fresh aortic valves.1-4 AOA tissue treatment has been shown in animal studies to result in significant reductions in calcium deposits on the valve.5-7


No clinical data is available which evaluates the long-term impact of the Physiologic Fixation process or the impact of AOA treatment in patients.


Yoganathan AP, Eberhardt C, Walker PG. Hydrodynamic performance of the Medtronic Freestyle aortic root bioprosthesis. J Heart Valve Dis.1994; 3:571-580.


Vesely I. Analysis of the Medtronic Intact bioprosthesis valve: Effects of zero-pressure fixation. J Thorac Cardiovasc Surg. 1991;101:90-99.


Mayne ASD, Christie GW, Smaille BH, et al. An assessment of the mechanical properties of leaflets from four second-generation porcine bioprostheses using biaxial testing techniques. J Thorac Cardiovasc Surg. 1989;98:170-180.


Christie GW. Anatomy of aortic heart valve leaflets: The influence of glutaraldehyde fixation on function. Eur J Cardiothorac Surg.1992;6(suppl):S25-33.


Data on file, Medtronic, Inc.


Duarte IG, MacDonald MJ, Cooper WA, et al. In vivo hemodynamic, histologic, and antimineralization characteristics of the Mosaic bioprosthesis. Ann Thorac Surg. 2001;71:92-99.


Chen W, Schoen FJ, Levy RJ. Mechanism of efficacy of AOA for inhibition of calcification of glutaraldehyde-pretreated porcine bioprosthetic heart valves. Circulation. 1994;90:323-329.

Information on this site should not be used as a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.