For the first time, infants with acute kidney injury (AKI) and fluid overload (FO) can be treated with a dialysis system designed specifically for them.1
The first of its kind, the Carpediem™ system offers a dedicated extracorporeal CRRT to low weight patients and responds to the needs of the most fragile patient.
Neonatal acute kidney injury (AKI) and fluid overload are under-recognized conditions which often lead to morbidity and mortality.3
For the first time, there is no need to adapt adult machines and weigh the complexities that have traditionally plagued pCRRT treatments.7
† 50% Carpediem™ system patients survived to ICU discharge. Mortality after pCRRT discontinuation due to critical illness with underlying pathologies – many not amenable to treatment. Garzotto F, Zaccaria M, Vidal E, et al. Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better. Pediatr Crit Care Med. 2019;20(3):170-179.
1. Ronco C, Garzotto F, Ricci Z. CA.R.PE.DI.E.M. (Cardio-Renal Pediatric Dialysis Emergency Machine): evolution of continuous renal replacement therapies in infants. A personal journey. Pediatr Nephrol. 2012;27(8):1203–1211.
2. Carpediem™ dialysis system [Operator’s Manual].
3. Nada A, Bonachea EM, Askenazi DJ. Acute kidney injury in the fetus and neonate. Sem Fetal Neonatal Med. 2017;22(2):90-97.
4. Goldstein SL, Vidal E, Ricci Z, et al. Survival of infants treated with CKRT: comparing adapted adult platforms with the Carpediem™. Pediatr Nephrol. 2022;37(3):667-675.
5. Vidal E, Cocchi E, Paglialonga F, et al. Continuous veno-venous hemodialysis using the Cardio-Renal Pediatric Dialysis Emergency Machine™: first clinical experiences. Blood Purif. 2018;31:1–7.
6. Garzotto F, Zaccaria M, Vidal E, et al. Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better. Pediatr Crit Care Med. 2019;20(3):e170-e179.
7. Ronco C, Garzotto F, Brendolan A, et al. Continuous renal replacement therapy in neonates and small infants: development and first-in-human use of a miniaturised machine (CARPEDIEM). Lancet. 2014;383:1807–1813.