Innovations in Pediatric CRRT

For the first time, infants with acute kidney injury (AKI) and fluid overload (FO) can be treated with a dialysis system designed specifically for them.1

A miniaturized, high-precision platform1,2

For the Most Fragile Patients

The first of its kind, the Carpediem™ system offers a dedicated extracorporeal CRRT to low weight patients and responds to the needs of the most fragile patient.

  • CVVH, CVVHD, and SCUF modalities
  • Low priming volume & pump flow
  • High-precision scales
  • Continuous or bolus Heparin pump delivery

View Clinical Summary

When Size and Scale Matter

Neonatal acute kidney injury (AKI) and fluid overload are under-recognized conditions which often lead to morbidity and mortality.3

Tailored Performance.
Precise Control.

  • Clinical data  demonstrates a 97% survival rate at end of treatment4,†
  • Closely monitor fluid balance: +/- 1 g High-precision scales 
  • Enable use of small catheter sizes5
  • Reduce blood cell and vessel damage while providing necessary and adequate diffusive clearances: 2–50 ml/min low blood flow rates1,2,6

A renewed focus on what is most important

For the first time, there is no need to adapt adult machines and weigh the complexities that have traditionally plagued pCRRT treatments.7

Carpediem™ System Details

  1. IV pole holder
  2. Warning light
  3. Control panel
  4. Clip for effluent (EFF) pump segment
  5. Effluent (EFF) scale
  6. Infusion/dialysis (INF/DIA) scale
  7. Venous pressure transducer (Dome)
  8. Effluent (EFF) pump
  9. Heparin pump
  10. Filter holder
  11. Venous drip chamber holder
  12. Clip for the infusion/dialysis (INF/DIA) pump segment
  13. Blood leakage detector (BLD)
  14. Air sensor
  15. Infusion/dialysis (INF/DIA) pump
  16. Blood pump
  17. Arterial pressure transducer (Dome)
  18. Pre-filter pressure transducer (Dome)
  19. Venous electroclamp
  20. Clip for infusion/dialysis (INF/DIA) line if a warmer is used
  21. Clip for venous line
  22. Warmer holder
  • † 50% Carpediem™ system patients survived to ICU discharge. Mortality after pCRRT discontinuation due to critical illness with underlying pathologies – many not amenable to treatment. Garzotto F, Zaccaria M, Vidal E, et al. Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better. Pediatr Crit Care Med. 2019;20(3):170-179.

  • 1. Ronco C, Garzotto F, Ricci Z. CA.R.PE.DI.E.M. (Cardio-Renal Pediatric Dialysis Emergency Machine): evolution of continuous renal replacement therapies in infants. A personal journey. Pediatr Nephrol. 2012;27(8):1203–1211.

  • 2. Carpediem™ dialysis system [Operator’s Manual].

  • 3. Nada A, Bonachea EM, Askenazi DJ. Acute kidney injury in the fetus and neonate. Sem Fetal Neonatal Med. 2017;22(2):90-97.

  • 4. Goldstein SL, Vidal E, Ricci Z, et al. Survival of infants treated with CKRT: comparing adapted adult platforms with the Carpediem™. Pediatr Nephrol. 2022;37(3):667-675.

  • 5. Vidal E, Cocchi E, Paglialonga F, et al. Continuous veno-venous hemodialysis using the Cardio-Renal Pediatric Dialysis Emergency Machine™: first clinical experiences. Blood Purif. 2018;31:1–7.

  • 6. Garzotto F, Zaccaria M, Vidal E, et al. Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better. Pediatr Crit Care Med. 2019;20(3):e170-e179.

  • 7. Ronco C, Garzotto F, Brendolan A, et al. Continuous renal replacement therapy in neonates and small infants: development and first-in-human use of a miniaturised machine (CARPEDIEM). Lancet. 2014;383:1807–1813.