Gain Easy Access to the Benefits of BIS™ Technology

The BIS™ LoC (Level of Consciousness) 4 channel OEM module and BIS™ bilateral sensor provide the capability to detect hemispheric differences in the brain, which may prove useful for advanced monitoring applications.

Delivered in the same compact, portable, plug-and-play design as the BIS™ LoC 2 channel OEM module, the BIS™ LoC 4 channel OEM module provides advanced bilateral features, including four-channel EEG monitoring, a color-scaled density spectral array, and the BIS™-proprietary asymmetry indicator.


Confidently monitor and tailor safe, optimal anesthesia for each patient with BIS™ brain monitoring.

Find Out How


Order Information

How to Order

For additional information or to place an order, call Customer Service at +44 (0) 19 2320 2504.

Order Information
Order Code Description Unit of Measure Quantity
186-0195-SF BISx (Standard Format) Each 1
186-0107 Patient Interface Cable (PIC+) Each 1
186-0202 Replacement Bulkhead Connector Each 1
The following information is provided to the patient monitor by the BISx™ system:
Bispectral Index (BIS) 0 to 100
Electromyographic Strength (EMG)) 30 to 80 dB (where 1 μV2 = 40 dB)
Signal Quality Index (SQI) 0 to 100%
Suppression Ratio (SR) 0 to 100%
Spectral Edge Frequency (SEF) 0.5 to 30.0 Hz
Total Power 40 to 100 dB (where 1 μV2 = 40 dB)
Burst Count 0 to 30 (with an Extend Sensor only)
EEG (Continuous, four channel, real-time EEG waveform)
EEG Scales—two or four channel display 50 μV/div (+/- 50 μV per waveform)
Noise (EEG waveform) < 0.3 μV RMS (2.0 μV peak-to-peak): 0.25 Hz to 50 Hz
BIS Numeric Update Frequency Once per second
EEG Bandwidth 0.25 Hz to 100 Hz (-3 dB) +/- 10%
Electrode to skin impedances are continuously measured  
Additional BISx™ 4 Channel Parameters
The following information is provided to the patient monitor by the BISx system:
EEG (Continuous, four channel, real-time EEG waveform)— Left BIS data in yellow; Right BIS data in blue
BIS Left (L) , BIS Right ( R) values—user selectable
Dual BIS Trends—BIS Left (L), BIS Right (R)
Density Spectral Array (DSA)—color-scaled graphical representation of EEG frequency differences between the left and right hemispheres
Asymmetry Indicator (ASYM)—black-and-white graphical representation of the relative total power of EEG between the left and right hemispheres
Users can select from a range of low-pass and high-pass filters that are available for artifact rejection. The low-pass filters allow the rejection of muscle artifacts. The high-pass filters allow the rejection of ECG signal interference. In addition, a notch filter suppresses line frequency interference.
The BIS XP technology built into the BISx system suppresses interference from elecrocautery, EMG and other high frequency noise sources.
Physical Specifications
BISx System ( 2 Channel and 4 Channel)
Size 98 mm (3.85 in.) diameter x 63.5 mm (2.5 in.) height (including clamp)
Weight 211 g (7.44 oz) without cables; 434 g (0.96 lb) with cables
Integrated clamp Can accommodate pole up to 32 mm (1.25 in.) in diameter
BISx Integral Cables (2 Channel and 4 Channel)
Host Monitor Cable 2.7 m (9 ft) with Hypertronics Hypergrip connector
Patient Interface Cable (PIC+ and PIC-4 ) 1.4 m (4.5 ft)
Safety Specifications
The BISx system complies with the essential requirements of the Medical Devices Directive 93/42/EEC, as amended by Directive 2007/47/EC, as well as IEC 60601-2 26:2002 and IEC 60601-1-2003. It is a Type BF applied part. It has internal optical coupling and an isolation transformer for patient isolation. It is protected against damage from defibrillation as long as the sensor is not located between the defibrillator pads and is resilient to artifact from electrosurgery.
Data Exchange Summary
The BISx system communicates with the host monitor through asynchronous serial communication (RS-232). The protocol is packet oriented with binary data and ACK/NAK handshaking. The host monitor can:
• Choose the communication protocol by an input select line in the host cable
• Request BISx hardware and software revision information
• Send commands to the BISx system to change smoothing rate (making the BIS parameter more or less sensitive to sudden changes in patient measurements), change filter settings and initiate a sensor check
The information specified above in the “Output Parameters” section is transmitted from the BISx system to the host once per second. Each of these processed variables packets is 198 bytes long. Additionally, the BISx system will transmit EEG waveform data to the host eight times per second. Each of these raw EEG packets is 154 bytes long.
Interface Specifications
BISx Host Connector ( 2 Channel and 4 Channel)
Size Hypertronics Hypergrip connector 12 pin barrel-style connector.
Input Power Requirements

The BISx system adheres to the power requirements of the USB 1.1 Spec.
Voltage Input +5VDC +/- 5%
Max Current Draw 500 mA
Supply Voltage Ripple <100 mV at all frequencies
Communication Requirements
Protocol RS-232
RS-232 Communication
Rate Rate 57.6 Kb/sec
Data Data 8 bit
Stop Stop 1 bit
Parity Parity No
Flow Control Flow Control None
USB Communication
Rate Up to 12 Mb/sec
Environmental Specifications
Temperature Range
Operating 0 to 40° C (32 to 104° F)
Storage -10 to 60°C (-50 to 140°F)
Operating 10 to 95% RH at 40°C (104° F), non-condensing
Storage 10 to 95% RH at 60°C (140° F), non-condensing
Altitude Range
Storage Up to 6,130 m (20,000 ft)

Product Features

The BIS™ LoC (Level of Consciousness) 4 channel OEM module system is designed for easy integration into monitoring systems. It includes the OEM or standard host monitor cable, the main 4 channel BISx processing unit with integrated clamp, and the 4 channel patient interface cable (PIC4) that accepts the BIS™ bilateral sensor.

The BIS™ LoC 4 channel OEM module system provides all the BIS™ technology performance advantages and clinical benefits, plus additional advanced BIS™ brain monitoring features, including:

  • The ability to acquire and display up to four channels of raw EEG with waveform display. Two channels collected from the right and two channels from the left.
  • BIS™ available from either side of the brain to monitor levels of consciousness — BIS-L and BIS-R Values. Bilateral monitoring allows clinicians to trend both sides of the brain, using the Dual BIS™ Trend.
  • New parameter tools to assess hemispheric differences, including the density spectral array and asymmetry indicator (see below).

Advanced features provided by the BIS™ LoC 4 channel OEM module include:

  • The Density Spectral Array (DSA)—a graphical representation of a patient’s EEG frequency and power differences between the two brain hemispheres.
  • The Asymmetry (ASYM) Indicator—a proprietary BIS parameter, in black and white graph form, which provides a simple, quick, and easy-to-assess depiction of hemispheric differences in total power of the EEG between the left and right hemispheres.

The easy-to-use, uniquely designed BIS™ Bilateral Sensor:

  • Collects four channels of frontal EEG.
  • Is designed for symmetrical placement to capture bi-hemispheric data, providing easy, accurate BIS™ bilateral sensor placement.


"BIS™ monitoring is recommended as an option for all patients receiving total intravenous anesthetic (TIVA). BIS™ technology is also cost effective in this patient population due to the inability to measure end-tidal anesthetic concentration."([FOOTNOTE=National Institute for Health and Clinical Excellence. Depth of anaesthesia monitors (E-Entropy, BIS™ and Narcotrend) (DG6). November 2012. Available at: http://guidance.nice.org.uk/DG6.],[ANCHOR=],[LINK=])

– National Institute for Health and Clinical Excellence