The sheath and core of Polysorb™ suture utilize a manufacturing process that produces more finer, stronger filaments and provides Polysorb™ with superior tensile strength.
Syneture's tensile strength for Polysorb™ is based on a percentage of the USP standard for knot pull strength. It is an industry measurement standard and measures the actual strength of the suture both out-of-package and over time. The competitor's tensile strength claim for their product is not based on the actual strength of the suture over time but instead on the percentage of it's own original strength. If the competitive product lists it's strength at 75% at 2 weeks that means it has 75% of its original strength. In its registration the competition does not use any industry standard as a base point for measurement. In an "apples to apples" test of tensile strength measuring how many kilograms of force it takes to break a suture line, Polysorb™ is appreciably stronger out-of-package and during the critical wound healing period.
There have been several improvements made to Polysorb™ in the past few years. The original core-to-sheath ratio was 80% core to 20% sheath. This made the suture more supple but the suture was prone to slipping and separating from the core. The current core-to-sheath ratio is 20% core to 80% sheath. This ratio is equivalent to the competitor's braided synthetic abrsorbable suture. Polysorb™ suture's braid construction and coating were improved to provide better flow through tissue and a more secure knot. When tied down with proper technique, Polysorb™ has a stronger, more secure knot.
Polysorb™ is made up of essentially the same chemical composition as the competitor's product. They are both absorbed by hydrolysis and their absorption profiles are both between 56-70 days. In-vivo testing has shown no measurable difference in reactivity between Polysorb™ and the competitor's braided synthetic absorbable suture.