SEOUDY

ANALYSIS<sup>1</sup>    

In this retrospective, single-center analysis, SEVs were associated with lower rates of procedural PPM than BEVs.

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This may be attributed to the supra-annular design of the Medtronic CoreValve™/Evolut™ R TAV, resulting in large iEOAs.

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Evolut R TAV has the benefit across all annular sizes —

  • Similar PVR for small and large annuli for Evolut R TAV vs. Sapien 3 TAV
  • Significantly lower incidence in PPM across small and large annulus ranges
  • Hemodynamic benefit for small and large annuli
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CHOICE EXTEND

REGISTRY<sup>3</sup>

In a recent prospective, nonrandomized registry, it was reported that the incidence of patient-prosthesis mismatch is higher with Sapien™* 3 TAV compared to Evolut™ R and PRO valves.

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STS/ACC TVT
REGISTRY™*

A recently published paper by Herrmann, et al.4 used STS/ACC TVT Registry™* data to examine the frequency and predictors of PPM and its associated outcomes.

The data shows that severe PPM is associated with higher mortality and that patient outcomes may improve when PPM is reduced.

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*

The analysis set for this data included all patients enrolled in the registry between January 1, 2014 and March 31, 2017 and included all U.S. commercial valves.

1

Seoudy H, Güßefeld N, et al. Incidence and impact of prosthesis–patient mismatch following transcatheter aortic valve implantation. Clinical Research in Cardiology. November 15, 2018.

2

Pibarot, P. The CHOICE Between Self-Expanding and Balloon-Expandable Valves for Transcatheter Aortic Valve Replacement*. Editorial Comment. JACC. Nov 2018.

3

Abdelghani M, Allali A, Kaur J, et al. Impact of prosthesis-iteration evolution and sizing practice on the incidence of prosthesis–patient mismatch after transcatheter aortic valve replacement. Catheter Cardiovasc Interv. Published online November 23, 2018.

4

Herrmann HC, Daneshvar SA, Fonarow GC, et al. Prosthesis-Patient Mismatch in 62,125 Patients Following Transcatheter Aortic Valve Replacement: From the STS/ACC TVT Registry. J Am Coll Cardiol. Published online September 23, 2018.

5

Flameng W, Herregods MC, Vercalsteren M, Herijgers P, Bogaerts K, Meuris B. Prosthesis-patient mismatch predicts structural valve degeneration in bioprosthetic heart valves. Circulation. May 18, 2010;121(19):2123-2129.

6

Pibarot P, Dumesnil JG. Prosthesis-patient mismatch: definition, clinical impact, and prevention. Heart. August 2006;92(8):1022-1029.

7

Abdelghani M, Mankerious N, Allali A, et al. Bioprosthetic valve performance after transcatheter aortic valve replacement with self-expanding versus balloon-expandable valves in large versus small aortic annuli: insights from the CHOICE trial and the CHOICE-extend registry. JACC Cardiovasc Interv. December 24, 2018;11(24):2507-2518.

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