VenaSeal Closure System

IMMEDIATE CLOSURE
VenaSeal
Closure System


Non-thermal
Non-tumescent
Non-sclerosant

IMMEDIATE CLOSURE

The VenaSeal™ closure system provides immediate vein closure, delivering consistent and reproducible results for your patients without the need for post-procedure compression stockings.1,2*

Venaseal Procedure Animation

View this VenaSeal Closure System procedure animation to see how it works.
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Precision

The proprietary catheter is highly visible under ultrasound, allowing precise delivery of the adhesive. The dispensing gun precisely controls the amount of adhesive, delivering 0.10 cc aliquots with each trigger pull.

Venaseal Adhesive Placed

Viscosity

The viscosity of the adhesive is specifically designed to minimize migration and embolization.

VenaSeal Adhesive with Syringe

Polymerization

Upon contact with blood, the adhesive begins to bond with the intima and compression is applied to close the vein. The adhesive was designed to remain permanently in the diseased vein and is encapsulated by chronic fibrosis.3

VenaSeal Polymerization

Flexibility

The adhesive is designed to be soft and flexible, and less likely to be felt by the patient.

Man stretching

THE RESULTS YOU HAVE COME TO EXPECT

VeClose 36-Month Results (IDE Clinical Trial)4

  • One of the largest multicenter, randomized prospective comparisons of superficial venous ablation technologies
  • No DVT, PE or adhesive-related allergies  were reported in the VenaSeal closure system study arm
  • 94.4% closure rate at 3 years
VeClose 36-Month Study Results

Definition of Occlusion

VeClose Occlusion >10

No discrete segment of patency >10 cm in the treated vein segment

VenaSeal Occlusion >5

No discrete segment of patency >5 cm in the treated vein segment

Study Design

  • FIH: Prospective, single-center study
  • eSCOPE: Prospective, multicenter, post‑market study
  • VeClose: Prospective, multicenter, randomized controlled trial
  • WAVES: Prospective, single-center, multi‑investigator, post‑market study

*

Some patients may benefit from the use of compression stockings post-procedure.


1

Proebstle, T.M. The European Multicenter Study on Cyanoacrylate Embolization of Refluxing Great Saphenous Veins without Tumescent Anesthesia and without Compression Therapy. Results presented at: Charing Cross; 2016; London, UK. 

2

Almeida, J.I., Jacier, J.J., Mackay, E.G., Bautista, C., Cher, D.J. and Proebstle, T.M. Thirty-Sixth Month Follow-up of First-in-human Use of Cyanoacrylate Adhesive for Treatment of Saphenous Vein Incompetence. J Vasc Surg: Venous and Lymphatic Disorders. 2017. Published Online: 2 June 2017.

3

Lui, D.M., et al. Cyanoacrylate Embolization for the Treatment of Saphenous Vein Reflux: Ultrasound Appearance and Correlative Findings of Comparative Model Histology. ACP 2014.

4

Morrison, N. VenaSeal Closure System vs. Radiofrequency Ablation for Incompetent Great Saphenous Veins (VeClose). 36 Month Results presented at: IVC; April 20,2017; Miami, FL.

5

Gibson, K., and Ferris, B. Cyanoacrylate Closure of Incompetent Great, Small and Accessory Saphenous Veins Without the Use of Post-procedure Compression: Initial Outcomes of a Post-market Evaluation of the VenaSeal System (the WAVES Study). Vascular (2016) May 20, Epub 2016 May, 1708538116651014.