BARRETT’S ESOPHAGUS GASTROINTESTINAL & HEPATOLOGY SOLUTIONS

TREATING BARRETT’S ESOPHAGUS

Gastroesophageal reflux disease (GERD) is a serious condition. The lifetime risk of progression from GERD to Barrett's esophagus is 26.5%.1 Progression of Barrett’s esophagus to esophageal adenocarcinoma (EAC) can be deadly. Patients with first-degree family history of EAC are 5.5 times more likely to progress from Barrett’s to EAC.3 For every one-centimeter increase in Barrett’s esophagus length, a patient experiences a 28% increase in risk of progression to EAC or high-grade dysplasia (HGD).2

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BARRX RADIOFREQUENCY ABLATION SYSTEM

Barrx Radiofrequency Ablation System illustration within an esophagus

Proactively reduce the risk of Barrett’s esophagus progression with radiofrequency ablation.4-6 RFA can eradicate Barrett’s esophagus and reduce the relative risk of disease progression to HGD/EAC by up to 94%.7

1

Dymedex Market Development Consulting, GERD Sizing and Segmentation for pH Testing, February 13, 2015.

2

Anaparthy R, Gaddam S, Kanakadandi V, et al. Association between length of Barrett’s Esophagus and risk of high-grade dysplasia or adenocarcinoma in patients without dysplasia. Clin Gastroenterol Hepatol. 2013;11(11):1430-6.

3

Tofani C, Gandhi K, Spataro J, et al. Esophageal adenocarcinoma in a first degree relative increases risk for progression to esophageal adenocarcinoma in patients with Barrett’s Esophagus. Am J Gastroenterol. 2017; Abstract 309:112(1)

4

ShaheenNJ, Sharma P, et al. Radiofrequency ablation in Barrett's esophagus with dysplasia. N Engl J Med. 2009 May 28;360(22):2277-2288

5

Phoa KN, van Vilsteren FG, Pouw RE, Weusten BL, et al. Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. JAMA. 2014 Mar 26;311(12):1209-17

6

Wolf WA, Lightdale CJ, Li N, et al. Incidence of Esophageal Adenocarcinoma (EAC) in Patients with Barrett’s Esophagus (BE) Undergoing Radiofrequency Ablation. Gastroenterology 2015 Aug 28.(15)1245-7

7

Phoa K, van Vilsteren FGI,Weusten BLAM, Bisschops R, Schoon EJ, Ragunath K, et al. Radiofrequency Ablation vs Endoscopic Surveillance for Patients With Barrett Esophagus and Low-Grade Dysplasia: A Randomized Clinical Trial. JAMA. 2014;311(12) 1209-1217. doi:10.1001/jama.2014.2511.

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Images do not represent all components of the system.