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RF ablation systems

Symplicity Spyral™ renal denervation system

<p>The Symplicity Spyral™ renal denervation (RDN) system is used during the Symplicity™ blood pressure procedure for the treatment of hypertension.</p>

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See how the system works.

Watch a short video to see how the Symplicity Spyral™ system works during the Symplicity™ procedure.

Symplicity Spyral™ multi-electrode renal denervation catheter

  • One catheter size fits vessels 3–8 mm5
  • 4 F catheter,† compatible with 6 Fr guide catheter, 0.014" guidewire
  • Easy-to-use, plug-and-play design
  • Nonocclusive design allows for continuous blood flow to naturally protect the vessel wall1
This is an image of the Medtronic Symplicity Spyral™ renal denervation catheter with blue gradient spirals circling it.

Symplicity G3™ renal denervation RF generator

  • Unique, real-time, and responsive algorithm automatically adjusts power by monitoring temperature and impedance for safe energy distribution.1
  • Multi-electrode, helical design covers four quadrants simultaneously for a circumferential ablation.1,5
  • Radiofrequency energy preferentially heats fat tissue where renal nerves are located and avoids nontarget structures.‡,6
  • Only the Symplicity Spyral™ RDN system allows for denervation throughout the renal anatomy with a single catheter, including the distal branches,5 where late arriving nerves are accessible and total nerve density is highest.7,8
This is an image of the Symplicity G3™ renal denervation RF generator.

Proven to deliver significant, safe, and sustained blood pressure reductions2,3,9,10

  • Multiple randomized, sham-controlled clinical trials
  • Real-world experience with more than 5,000 patients enrolled in the SPYRAL HTN clinical program§,◊,2,3,10–14
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Results may vary.

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Symplicity Spyral™ system products

Item number Description
RDN016 Symplicity Spyral™ multi-electrode RDN catheter
RDNG3A Symplicity G3™ generator, supplied standard with remote control
RDN019 Mobile cart for Symplicity G3™ generator  (optional accessory)

 

Additional products used during the Symplicity™ procedure

Item number Description
SB6RDND1K Sherpa NX™ balanced 6 Fr 55 cm guide catheter with RDND1 curve
LA6IMAK Launcher™ 6 Fr 55 cm guide catheter with IMA curve
SB6IMAK Sherpa NX™ balanced 6 Fr 55 cm guide catheter with IMA curve
E7507 and
E7507DB		 Dispersive electrode for RDNG3A: Compatible with ValleyLab Polyhesive™ adult patient return electrode

 

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Review clinical evidence.

The Symplicity Spyral™ RDN system is backed by multiple sham-controlled trials and a real-world registry.

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See how renal denervation can help.

Learn more about the turning point in hypertension care and how it can help enhance treatment strategies.

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Additional resources

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† Catheter dimension of 0.052" is average maximum diameter determined during design verification. Upper bound allowable is 0.061".

‡ Preclinical data may not be indicative of clinical performance.

§ Includes Symplicity Spyral™ and Flex™ catheters.

◊ Study follow-up is ongoing. Data does not represent follow-up for all patients.

  1. Coates P, Tunev S, Trudel J, Hettrick DA. Time, temperature, power, and impedance considerations for radiofrequency catheter renal denervation. Cardiovasc Revasc Med. 2022;42:171–177. doi:10.1016/j.carrev.2022.02.018.
  2. Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham controlled trial. Lancet. 2020;395(10234):1444–1451. doi:10.1016/S0140-6736(20)30554-7.
  3. Kandzari D, Townsend R, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medications. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.
  4. Based on RDN catheter historical data, Feb 2025. Data includes both Symplicity™ Flex and Symplicity Spyral™. Medtronic data on file.

  1. Symplicity Spyral™ multi-electrode renal denervation catheter instructions for use. Medtronic. November 18, 2023.
  2. Sato Y, Sharp A, Mahfoud F, et al. Translational value of preclinical models for renal denervation: a histological comparison of human versus porcine renal nerve anatomy. Eurointervention. 2023;18(13):e1120–e1128. doi:10.4244/EIJ-D-22-00369.
  3. García-Touchard A, Maranillo E, Mompeo B, Sañudo JR. Microdissection of the human renal nervous system: Implications for performing renal denervation procedures. Hypertension. 2020;76(4):1240–1246. doi:10.1161/HYPERTENSIONAHA.120.15106.
  4. Struthoff H, Lauder L, Hohl M, et al. Histological examination of renal nerve distribution, density, and function in humans. EuroIntervention. 2023;19(7):612–620. doi:10.4244/EIJ-D-23-00264.
  5. Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399(10234):1401–1410. doi:10.1016/S0140-6736(22)00455-X.
  6. Mahfoud F, Schlaich M, Schmieder RE, et al. Long-term outcomes in ESC guideline-recommended patients for RDN from Global SYMPLICITY Registry DEFINE. Presented at: EuroPCR 2025; May 20–23, 2025; Paris, France.
  7. Kario K, Ogawa H, Okumura K, et al. SYMPLICITY HTN-Japan - First randomized controlled trial of catheter-based renal denervation in Asian patients -. Circ J. 2015;79(6):1222–1229. doi:10.1253/circj.CJ-15-0150.
  8. Bhatt DL, Kandzari DE, O’Neill WW, et al. A controlled trial renal denervation for resistant hypertension. N Engl J Med. 2014;370(15):1393–1401. doi:10.1056/NEJMoa1402670.
  9. Esler MD, Böhm M, Sievert H, et al. Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial. Eur Heart J. 2014;35(26):1752–1759. doi:10.1093/eurheartj/ehu209.
  10. Krum H, Schlaich MP, Sobotka PA, et al. Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study. Lancet. 2014;383(9917):622–629. doi:10.1016/S0140-6736(13)62192-3.