Pipeline™ Embolization Device Family offers a comprehensive size range from 2.50mm to 5.00mm diameters in 0.25mm increments and lengths up to 35mm1. Thus, providing tailored treatment options for diverse patient anatomies. The importance of "right size device" is critical when considering efficacy, safety, and braid change2.

Pipeline™ deployment: How to

Pipeline Flex™ with Shield Technology™ (ICA 1)

Pipeline Flex™ with Shield Technology™ (ICA 2)

Pipeline Vantage™ 021

The Pipeline™ advantage 

Like baking a cake, there are many ingredients that can be used & changing them alters the flavour. Material selection matters.

Pipeline™ flow diverters, are typically constructed from a braided mesh of cobalt-chromium and platinum alloy wires. The PED and similar devices utilize this material for its biocompatibility and radiopacity (allowing for visualization during procedures). The advantage of this material composition lies in its ability to create a porous, yet robust, structure that effectively diverts blood flow away from the aneurysm while maintaining patency of the parent artery3.

Braided mesh design for flexibility and adaptability4

The braided mesh design allows for a high degree of flexibility and adaptability to the shape of the vessel, while maintaining a porous structure that allows blood to pass through but diverts flow from the aneurysm. 

Cobalt chromium for better healing and efficacy5

Pipeline™ devices are made of Cobalt Chromium, which has higher tensile strength than Nitinol. This strength allows for thinner device braids, aiding in neointimal healing.

The aim when using a nitinol flow diverter, is to place a stent. The aim when placing a cobalt chromium flow diverter, is to reconstruct an artery”

— Prof. Hal Rice Gold Coast University Hospital, Australia

Chronic outward force6

COF indicates how well the braid is anchored in its position and the higher the COF, the better the wall apposition during deployment. Pipeline™ devices have superior COF vs. other devices.

Radial resistance force6

RRF helps to ensure that the stent maintains its integratory post implantation & as it resists squeezing by constriction of the vessel to enable long term braid stability. Pipeline™ devices have superior RRF vs. other devices.

References:

  1. Pipeline™ Vantage Embolization Device with Shield Technology™ device IFU; M067713CDOC2_B. Pipeline™ Flex  with Shield Technology™ device IFU; M053137CDOC2_B
  2. F. Mut, J.R. Cerbral Effects of Flow-Diverting Device Oversizing on Hemodynamics Alteration in Cerebral Aneurysms American Journal of Neuroradiology Nov 2012, 33  (10) 2010-2016; DOI: 10.3174/ajnr.A3080
  3. Oliver AA, Senol YC, Bilgin C, Schaffer JE, Kadirvel R, Kallmes DF, Wainwright JM. Intraluminal Flow Diverter Design Primer for Neurointerventionalists. AJNR Am J Neuroradiol. 2024 Apr 8;45(4):365-370. doi: 10.3174/ajnr.A8076. PMID: 38164542; PMCID: PMC11288553.
  4. Dandapat, S. et al. (2021) Review of current intracranial aneurysm flow diversion technology and clinical use, Journal of NeuroInterventional Surgery. Available at: https://jnis.bmj.com/content/13/1/54 (Accessed: 16 September 2025).
  5. Dibas, M. et al. (2025) ‘Use of cobalt–chromium 64 wires surpass evolve for the treatment of remnant intracranial aneurysms: A subanalysis from the Sease International Registry’, Stroke: Vascular and Interventional Neurology, 5(2). doi:10.1161/svin.124.001470.
  6. D00526089_B_COF & RRF + Supporting Excel COF and RRF for 325 500 devices