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BIS™ technology offers clinicians added security for providing specialized care and comfort for their patients, including those who may be more sensitive to the hemodynamic effects of anesthesia.

BIS™ monitoring provides valuable information about the patient status to help clinicians address each patient’s unique anesthetic requirements.

This technology may be particularly valuable for:

  • Patients with complex conditions whose status may suddenly or frequently change
  • Patients with cardiovascular conditions
  • Obese patients
  • Trauma patients or others requiring reduced levels of anesthesia

BIS™ is a complex monitoring technology intended for use as an adjunct to clinical judgment and training. Clinical judgment should always be used when interpreting BIS™ in conjunction with other available clinical signs. Reliance on BIS™ alone for intraoperative anesthetic management is not recommended. As with any monitored parameter, artifacts and poor signal quality may lead to inappropriate BIS™ values. Potential artifacts may be caused by poor skin contact (high impedance), muscle activity or rigidity, head and body motion, sustained eye movements, improper sensor placement and unusual or excessive electrical interference.

BIS™ values should also be interpreted cautiously with certain anesthetic combinations, such as those relying primarily on either ketamine or nitrous oxide/narcotics to produce unconsciousness. Due to limited clinical experience in the following applications, BIS values should be interpreted cautiously in patients with known neurological disorders and those taking other psychoactive medications.


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  • The BIS™ Quatro sensor offers:
    • Peel-­and-­stick simplicity
    • Zipprep™ technology
  • BIS™ sensors collect electroencephalograph (EEG) data.
  • BIS™ technology enables simple EEG data collection via a noninvasive sensor applied to the patient’s forehead.


How does our sensor technology work to capture the low-­voltage EEG signal?

First, we use a conductive ink that is printed directly on the surface of the sensor, under the adhesive foam and Zipprep™ technology. This creates an electrode surface that is helpful in picking up the low-­voltage EEG.

Second, the Zipprep technology helps clear away the first layer of the epidermis. The mechanical action of pressing on the electrode results in the tines clearing away some of the first layer of dead skin cells, exposing the inner, more electrically conductive layer of skin. The conductive gel within the electrode permeates into this newly exposed area, creating a good electrical pathway between the EEG-­carrying inner layers of skin and the conductive traces within the sensor. The EEG signal is then carried through these traces to the BIS™ monitor.

Third, we include a thin layer of sponge that contains a very precise amount of gel. This gel creates a "bridge" between the forehead and the conductive electrode surface.

These combined components help achieve an optimal environment to acquire and maintain the EEG signal.