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This episode looks in detail at the mechanisms and causes of obesity. Andrew and George discuss the role of basal metabolism in weight regulation, the Weight-Set Point Theory and the impact that the Western diet and ultra-processed foods (UPF) have on satiety regulation through leptin and insulin resistance.
Andrew and George delve into more detail on the Weight-Set Point Theory and explore how we’re bound by biology. Our body weight is, in part, determined by our genetics and modified by epigenetics, environmental factors, and food quality. They discuss how the potential detrimental impact of low-calorie dieting, even in healthy individuals, can ultimately lead to health deficit.
In the final episode, Andrew and George ask: Is leptin resistance with an omega-3 deficiency caused by Western diet the biggest driver of obesity? What part does inflammation play and why is this important? What can the new science of epigenetics tell us?