Smart insulin products

Smart MDI

<p>The Smart MDI system tracks both insulin and glucose data, to deliver personalized, real-time dosing guidance for patients. </p>

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Indications, Safety, and WarningsImportant safety information: InPen™ smart insulin pen
The InPen™ requires a prescription. It is a home-use reusable pen injector for single-patient use by people with diabetes under the supervision of an adult caregiver, or by a patient age 7 and older for the self-injection of a desired dose of insulin. The pen injector is compatible with Lilly Humalog® U-100 3.0 mL cartridges, Novo Nordisk Novolog® U-100 3.0 mL cartridges, and Novo Nordisk Fiasp® U-100 3.0 mL cartridges and single-use detachable and disposable pen needles (not included). The pen injector allows the user to dial the desired dose from 0.5 to 30 units in one-half (1/2) unit increments.The InPen™ dose calculator, a component of the InPen™ app, is indicated for the management of diabetes by people with diabetes under the supervision of an adult caregiver, or by a patient age 7 and older for calculating an insulin dose or carbohydrate intake based on user entered data.For an insulin dose based on amount of carbohydrates, a healthcare professional must provide patient-specific target blood glucose, insulin-to-carbohydrate ratio, insulin sensitivity parameters, and duration of insulin action to be programmed into the software prior to use as it is required for set up.For an insulin dose based on fixed/variable meal sizes, a healthcare professional must provide patient-specific fixed doses/meal sizes to be programmed into the software prior to use.For additional product and important safety considerations, see user guide and http://bit.ly/InPenSafety.Important safety information: Simplera™ System
The Simplera™ System requires a prescription. It consists of a sensor and mobile app that perform real-time continuous glucose monitoring (CGM) for the management of diabetes in adults ages 18 years and older. The sensor is indicated for up to 6 days of use, plus an additional grace period of 24 hours. It is intended for use in home environments. The Simplera™ system does not require calibration. Blood glucose (BG) readings are required (1) during the first 12 hours of use, (2) if no sensor data is available, (3) when symptoms do not match the sensor glucose (SG) value, and (4) when taking certain medications. Not taking BG readings as indicated can lead to incorrect sensor glucose readings, over-administration of insulin, and possible hypoglycemia.The Simplera™ app in combination with the Simplera™ sensor is intended for use only by patients and caregivers using a compatible mobile device and operating system, and who have sufficient experience to adjust mobile device audio and notification settings. When taking any of the following medications, consult a healthcare professional prior to using the system, as these can bias sensor glucose readings, potentially leading to the over-administration of insulin and a higher risk of hypoglycemia: acetaminophen, paracetamol, hydroxyurea, hydroxycarbamide. Sensor use can also result in skin irritation, bruising, discomfort, redness, bleeding, and infection, and sensors in general also pose a choking risk to young children, which can result in serious injury or death. For complete details, consult the user guide at https://www.medtronicdiabetes.com/support/download-library/user-guides and https://bit.ly/SimpleraSafetyImportant safety information: i-Port Advance™ injection port
i-Port Advance™ injection port is prescription-indicated for patients who administer, or to whom is administered, multiple daily subcutaneous injections of physician prescribed medications, including insulin. The device may remain in place for up to 72 hours to accommodate multiple drug injections without the discomfort of additional needle sticks. Site infection and/or irritation is a risk. Patients experiencing such symptoms should immediately consult their healthcare provider and/or discontinue use. For complete details, please consult the i-Port™ Advance product user guide.

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Take the guesswork out of insulin dosing

A diagram depicting a diabetes patient’s journey on dosing decisions

What is Smart MDI?

For people who manage their diabetes with insulin injections, Smart MDI helps alleviate the physical and mental effort required through an all-in-one solution that uses patients' glucose and insulin data to give personalized guidance.

There are many reasons a patient may choose MDI therapy, and this system can offer some of the advantages of insulin pump therapy while still giving users the freedom of daily injections. The integrated Smart MDI system works together to help your patients take the guesswork out of insulin dosing.

Smart MDI system components

The InPen app and smart insulin pen with the Bluetooth logo.

InPen™ smart insulin pen

Shareable reports
Data to make informed therapy decisions
Dose reminders
For late or missed mealtime doses
Half-unit doses
For those with insulin sensitivity

The Simplera sensor.

Simplera™ CGM

Easy-to-insert sensor
Two-step process that can take less than 10 seconds
Designed to replace fingersticks
Tracks glucose levels every 5 minutes, 24/7
Our smallest sensor
No overtape or transmitter needed

The i-Port advance injection port.

i-Port Advance™ injection port

93% reduction in needle pokes^†
It takes the shots for them
Comfortable and dependable^‡
Helps with compliance
Auto-insertion device included
For those with fear of pokes

Real-time blood glucose readings, trends, and alerts

❶ Helps prevent highs, alerting if trending high

❷ Helps prevent lows, alerting if at low, or trending low

An animated graph showing how Smart MDI can help prevent highs is trending high and help prevent lows if trending or at low.

Starting April 25, 2025, Medtronic will be discontinuing the sales of the Guardian™ Connect system, including the sensor and transmitter. The mobile app will no longer be available after October 24, 2025.

† Based on 150 injections per month versus 10 insertions per month.

‡ Survey data on file; individual results may vary.

Smart MDI

United States

Customer Care Team