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Answers to your questions about vein disease, and our treatments for varicose veins and venous leg ulcers


What is chronic venous insufficiency?

Healthy leg veins have valves that keep blood flowing to the heart. Chronic Venous Insufficiency develops when the valves stop working properly and allow blood to flow backward (i.e., reflux) and pool in the lower leg veins. If vein disease is left untreated, symptoms can worsen over time. As a result, vein valves will not close properly, leading to signs and symptoms such as:1

  • Varicose veins
  • Aching or pain
  • Swelling
  • Cramping
  • Heaviness or tiredness
  • Itching
  • Restlessness
  • Skin changes
  • Brown, colored skin
  • Open sores or ulcers

How prevalent is chronic venous insufficiency?

  • More than 190 million people have CVI or varicose veins globally. 
  • Varicose veins, a common symptom of CVI, can affect up to 40 percent of adults.4
  • Varicose veins are more common in those who are overweight, and in women who have had more than two pregnancies.4
  • Women usually have multiple risk factors for the development of varicose veins. In fact, varicose veins are most common in women (75 percent of those diagnosed) than in men (25 percent of those diagnosed).5
  • It is common for varicose veins to become more prominent during pregnancy and worsen with successive pregnancies.6

How is chronic venous insufficiency treated?

Chronic Venous Insufficiency treatment aims to reduce or stop the backward flow of blood. Treating the diseased vein improves overall blood flow and relieves symptoms.

For some patients, compression stockings alone may improve blood flow. For other patients, closing or removing the diseased vein may be necessary to improve blood flow. Closing or removing the diseased vein directs blood to nearby healthy veins.


What is the VenaSeal™ closure system?

The VenaSeal™ Closure System uses a proprietary medical adhesive to close the diseased vein.

What does it treat?

The VenaSeal™ Closure System treats symptomatic vein disease in the lower extremity superficial truncal veins, often the underlying cause of painful varicose veins.

What can I expect of the VenaSeal™ procedure?

Before the procedure:

You will have an ultrasound imaging exam of the leg that is to be treated. This exam is important for assessing the diseased superficial vein and planning the procedure.

During the procedure:

Your doctor can discuss the procedure with you. A brief summary of what to expect is below:

  • You may feel some minor pain or stinging with a needle stick to numb the site where the doctor will access your vein.
  • Once the area is numb, your doctor will insert the catheter (i.e., a small hollow tube) into your leg. You may feel some pressure from the placement of the catheter.
  • The catheter will be placed in specific areas along the diseased vein to deliver small amounts of the medical adhesive. You may feel some mild sensation of pulling. Ultrasound will be used during the procedure to guide and position the catheter.
  • After treatment, the catheter is removed and a small adhesive bandage placed over the puncture site.

After the procedure:

  • You will be taken to the recovery area to rest.
  • Your doctor will recommend follow-up care as needed.

When will my symptoms improve?

Symptoms are caused by the diseased superficial vein. Thus, symptoms may improve as soon as the diseased vein is closed.

When can I return to normal activity?

The VenaSeal™ Procedure is designed to reduce recovery time. Many patients return to normal activity immediately after the procedure. Your doctor can help you determine when you can return to normal activity.

Is the VenaSeal™ procedure painful?

Most patients feel little, if any, pain during the outpatient procedure.1 Is there bruising after the VenaSeal™ Procedure? Most patients report little-to-no bruising after the VenaSeal™ Procedure.7

What happens to the VenaSeal™ adhesive?

Only a very small amount of VenaSeal™ Adhesive is used to close the vein. Your body will naturally create scar tissue around the adhesive over time to keep the vessel permanently closed.

How does the VenaSeal™ procedure differ from thermal energy procedures?

The VenaSeal™ Procedure uses an adhesive to close the superficial vein. Thermal energy procedures use heat to close the vein. The intense heat requires a large volume of numbing medicine, which is injected through many needle sticks. The injections may cause pain and bruising after the procedure.

Is the VenaSeal™ procedure covered by insurance?

As with any procedure, insurance coverage may vary. For more information, please contact your insurance provider.


Is the ClosureFast™ procedure painful?

Most patients report feeling little, if any, pain during the ClosureFast™ procedure.8 Your physician should give you a local or regional anesthetic to numb the treatment area.

How quickly can I resume normal activity?

Patients treated with the ClosureFast™ procedure may resume normal activities more quickly than patients who undergo surgical vein stripping or laser ablation. With the ClosureFast™ procedure, the average patient typically resumes normal activities within a few days.For a few weeks following the treatment, your vein specialist may recommend a regular walking regimen and suggest you refrain from very strenuous activities (heavy lifting, for example) or prolonged periods of standing.

How soon after treatment will my symptoms improve?

Most patients report relief of symptoms after two days with a noticeable improvement in one to two weeks.

Is there any scarring, bruising, or swelling after the procedure?

Most patients report limited to no scarring, bruising, or swelling following the ClosureFast™ procedure using the ClosureFast™ catheter.9

How is the ClosureFastTM procedure different from endovenous laser?

Although the ClosureFast™ procedure and 980 nm endovenous laser ablation are both minimally invasive procedures, a comparative, multi-center study showed that the ClosureFast™ procedure was associated with statistically significant lower rates of pain, bruising, and complications. Patients undergoing the ClosureFast™ procedure also reported improvements in quality of life measures up to four times faster than patients treated with 980 nm endovenous laser ablation.8

How is the ClosureFastTM procedure different from vein stripping?

During vein stripping, incisions are made in the groin and calf, and a tool is threaded through the diseased vein to pull the vein out of the leg. With the ClosureFast™ procedure, only one small incision is made at the insertion site and the vein is then treated and left in place. This minimally invasive approach reduces the likelihood of pain and bruising associated with vein stripping surgery.10,11

Is the ClosureFast procedure covered by insurance?

Many insurance companies pay for the ClosureFast™ procedure in part or in full. The ClosureFast™ procedure has coverage policies with major health insurers. Please discuss your coverage with your insurance provider prior to seeking treatment.

Information on this site should not be used as a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.


Johns Hopkins Medicine Health Conditions and Diseases. Available at: Accessed May 14, 2019.


Gloviczki, P, Comerota, A, Dalsing, M, Eklof, B, Gillespie, D, Gloviczki, M, et al. The care of patients with varicose veins and associated chronic venous diseases: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011 May; 53 (5 Suppl): 2S-48S.


US Markets for Varicose Vein Treatment Devices 2011, Millennium Research Group. 2011.


Tisi, P. Varicose veins. Clin Evid (Online). 2011.


American College of Phlebology. Patient FAQs.


American College of Phlebology. Treatment of varicose and spider veins. Varicose_Vein_Brochure_Redesign.pdf


Morrison, et al. VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg


Almeida, J.I.,Kaufman, J., Göckeritz, O., et al. Radiofrequency endovenous ClosureFast versus laser ablation for the treatment of great saphenous reflux: a multicenter, single-blinded, randomized study (RECOVERY Study). J Vasc Interv Radiol. 2009;20:752-759.


L. H. Rasmussen, M. Lawaetz, L. Bjoern, B. Vennits, A. Blemings and B. Eklof, Randomized Clinical Trial Comparing Endovenous Laser Ablation, Radiofrequency Ablation, Foam Sclerotherapy and Surgical Stripping for Great Saphenous Varicose Veins. British Journal of Surgery Society Ltd., Wiley Online Library,, March 15, 2011


Lurie F, Creton D, Eklof B, Kabnick LS, Kistner RL, Pichot O, et al. Prospective randomized study of endovenous radiofrequency obliteration. (Closure procedure) versus ligation and stripping in a selected patient population (EVOLVeS Study). J Vasc Surg 2003;38;2:207-14.


Hinchliffe RJ, et al. A prospective randomised controlled trial of VNUS Closure versus Surgery for the treatment of recurrent long saphenous varicose veins. Eur J Vasc Endovasc Surg 2006 Feb;31;2:212-218.