Pediatric Continuous Renal Replacement Therapy (pCRRT)

Every patient matters. Every day matters.

Supporting an underserved pediatric need — the first of its kind. Dedicated and miniaturized extracorporeal pCRRT is finally available to clinically address acute kidney injury (AKI) and fluid overload (FO) for the smallest patients.1,2

A system better suited for fragile patients2

Addressing the increased risks and complexities of traditional pCRRT (adult machines adapted for pediatric use), the Carpediem™ system demonstrates a 97% neonate survival rate at end of treatment.3,4*

*50% of Carpediem™ system patients survived to ICU discharge. Mortality after pCRRT discontinuation due to critical illness with underlying pathologies — many not amenable to treatment.4

Learn more about the Carpediem™ system >

The Carpediem™ system is indicated for acute kidney injury or fluid overloaded patients requiring hemodialysis or hemofiltration therapy and weighing 2.5–10 kilograms. General contraindications for extracorporeal renal replacement therapies include, but are not limited to: hemodynamic instability, contraindication to suitable anticoagulation, and low platelet count.

A renewed focus on what is most important

Acute kidney disease in infants is common. And deadly.1

Neonatal acute kidney injury (AKI) and fluid overload are under-recognized conditions, with incidence rates as high as 40% and high mortality of up to 60%.1,5,6

  • *50% Carpediem™ system patients survived to ICU discharge. Mortality after pCRRT discontinuation due to critical illness withunderlying pathologies — many not amenable to treatment.

  • 1. Nada A, Bonachea EM, Askenazi DJ. Acute kidney injury in the fetus and neonate. Sem Fetal Neonatal Med. 2017;22(2):90-97.

  • 2. Ronco C, Garzotto F, Ricci Z. CA.R.PE.DI.E.M. (Cardio-Renal Pediatric Dialysis Emergency Machine): evolution of continuous renal replacement therapies in infants. A personal journey. Pediatr Nephrol. 2012;27(8):1203-1211.

  • 3. Ronco C, Garzotto F, Brendolan A, et al. Continuous renal replacement therapy in neonates and small infants: development and first-in-human use of a miniaturised machine (CARPEDIEM). Lancet. 2014;383:1807–1813.

  • 4. Goldstein SL, Vidal E, Ricci Z, Paglialonga F, Peruzzi L, Giordano M, Laforgia N, Ronco C. Survival of infants treated with CKRT: comparing adapted adult platforms with the Carpediem™. Pediatr Nephrol. 2022 Mar;37(3):667-675.

  • 5. Sutherland S, et al. AKI in hospitalized children comparing the pRIFLE, AKIN, and KDIGO definitions. CJASN. 2015; 10(4)554-61.

  • 6. Zappitelli M., Ambalavanan N., Askenazi D. et al. Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshop. Pediatric Res. 2017; 82(4):569-573.

  • 7. Selewski D., Charlton J., Jetton J., et al. Neonatal acute kidney injury. Pediatrics. 2015; 136(2): e463–473.