Innovations in Pediatric CRRT

For the first time, infants with acute kidney injury (AKI) and fluid overload (FO) can be treated with a dialysis system designed specifically for them.([FOOTNOTE=Ronco C, Garzotto F, Ricci Z. CA.R.PE.DI.E.M. (Cardio-Renal Pediatric Dialysis Emergency Machine): evolution of continuous renal replacement therapies in infants. A personal journey. Pediatr Nephrol. 2012;27(8):1203–1211.],[ANCHOR=],[LINK=])

A miniaturized, high-precision platform1,([FOOTNOTE=Carpediem™ dialysis system [Operator’s Manual]. Minneapolis, MN: Medtronic; 2020.],[ANCHOR=],[LINK=])

For the Most Fragile Patients

The first of its kind, the Carpediem™ system offers a dedicated extracorporeal CRRT to low weight patients and responds to the needs of the most fragile patient.

  • CVVH, CVVHD, and SCUF modalities
  • Low priming volume & pump flow
  • High-precision scales
  • Continuous or bolus Heparin pump delivery

View Clinical Summary

When Size and Scale Matter

Neonatal acute kidney injury (AKI) and fluid overload are under-recognized conditions which often lead to morbidity and mortality.([FOOTNOTE=Nada A, Bonachea EM, Askenazi DJ. Acute kidney injury in the fetus and neonate. Sem Fetal Neonatal Med. 2017;22(2):90-97.],[ANCHOR=],[LINK=])

Tailored Performance.
Precise Control.

  • Clinical data from the Carpediem™ system EU Registry demonstrates a 97% survival rate at end of treatment([FOOTNOTE=Based on internal report CARPEDIEM System DEN180055. CARPEDIEM System De Novo Application Clinical Data Section. 2020.],[ANCHOR=],[LINK=]),†
  • Closely monitor fluid balance: +/- 1 g High-precision scales 
  • Enable use of small catheter sizes([FOOTNOTE=Vidal E, Cocchi E, Paglialonga F, et al. Continuous veno-venous hemodialysis using the Cardio-Renal Pediatric Dialysis Emergency Machine™: first clinical experiences. Blood Purif. 2018;31:1–7.],[ANCHOR=],[LINK=])
  • Reduce blood cell and vessel damage while providing necessary and adequate diffusive clearances: 2–50 mL/min low blood flow rates1,2,([FOOTNOTE=Garzotto, F, Zaccaria M, et al. Choice of Catheter size for infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better. Pediatric Critical Care Medicine. 2019;20(3): 170-179.],[ANCHOR=],[LINK=])

A renewed focus on what is most important

For the first time, there is no need to adapt adult machines and weigh the complexities that have traditionally plagued pCRRT treatments.([FOOTNOTE=Ronco C, Garzotto F, Brendolan A, et al. Continuous renal replacement therapy in neonates and small infants: development and first-in-human use of a miniaturised machine (CARPEDIEM). Lancet. 2014;383:1807–1813.],[ANCHOR=],[LINK=])

Carpediem™ System Details

  1. IV pole holder
  2. Warning light
  3. Control panel
  4. Clip for effluent (EFF) pump segment
  5. Effluent (EFF) scale
  6. Infusion/dialysis (INF/DIA) scale
  7. Venous pressure transducer (Dome)
  8. Effluent (EFF) pump
  9. Heparin pump
  10. Filter holder
  11. Venous drip chamber holder
  12. Clip for the infusion/dialysis (INF/DIA) pump segment
  13. Blood leakage detector (BLD)
  14. Air sensor
  15. Infusion/dialysis (INF/DIA) pump
  16. Blood pump
  17. Arterial pressure transducer (Dome)
  18. Pre-filter pressure transducer (Dome)
  19. Venous electroclamp
  20. Clip for infusion/dialysis (INF/DIA) line if a warmer is used
  21. Clip for venous line
  22. Warmer holder

Clinical Support and Tailored Training

24/7 Guidance from Carpediem™ pCRRT Experts

Carpediem™ system support includes:

  • Tailored training specific to each individual care setting
  • On-site system installation
  • On-demand, 24-hour emergency access to experienced, registered Carpediem™ pCRRT nurses
  • †53% Carpediem system patients survived to ICU discharge. Mortality after pCRRT discontinuation due to critical illness with underlying pathologies – many not amenable to treatment. Refer to the operator’s manual for details.