In soft tissue repair, reliability is critical. Combining the tensile strength of synthetic hernia repair1 materials with the biocompatibility of an acellular porcine dermal implant, Permacol™ surgical implant delivers proven durability and strength for ventral hernia repair and abdominal wall reconstruction.
Permacol™ surgical implant is a porcine dermal collagen implant from which cells, cell debris, DNA and RNA are removed in a gentle process that is not damaging to the 3D collagen matrix. The resulting acellular collagen matrix is then cross-linked for enhanced durability.
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The cross-linking of Permacol™ surgical implant offers advantages over many other collagen-based implants for hernia and abdominal wall repair. Human cadaveric grafts and other non-crosslinked grafts may have initial success due to rapid tissue remodeling but may ultimately result in loss of tensile strength, increased tissue laxity and high recurrence rates that require additional surgical revisions.1-7 With its optimal cross-linking and gentle processing methods, Permacol™ surgical implant offers long-lasting dimensional stability that ensures the integrity of the collagen graft lasts through the body's wound healing process.
Requiring no rehydration or refrigeration, Permacol™ surgical implant is ready to use when needed and is dimensionally stable. It is available in a wide variety of sizes, including larger sizes that eliminate the need for suturing multiple pieces together and provide the right size of implant regardless of the size of the defect.
1. Ridgway DM et. al. In: Department of Surgery, North Lincolnshire and Goole Hospitals, ed. Scunthorpe, UK, 2005.
1a. Gaertner, W.G., et al. Experimental Evaluation of Four Biologic Prostheses for Ventral Hernia Repair. J. Gastrointest Surg. 2007.
2. Zheng, F, et al. Host Response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model. American Journal of Obstetrics and Gynecology(2004)191,1961-70.
3. Novi, J.M., et al. Vaginal Paravaginal Repair using Human Cadaveric versus Porcine Dermal Implant: A Survival Analysis. Ohio Research and Clinical Review Fall 2006.
4. Jin, J, et al. Abdominal Hernia Repair with Bridging Acellular Dermal Matrix - An Expensive Hernia Sac. American Hernia Society March 2007.
5. Jin, J, et al. Use of Acellular Dermal Matrix for Complicated Ventral Hernia Repair: Does Technique Affect Outcomes? Journal of the American College of Surgeons Volume 205, Issue 5, November 2007, Pages 654-660.
6. Rodriguez, Eduardo, et al. Abdominal Wall Reconstruction following Severe Loss of Domain: The R Adams Cowley Shock Trauma Center Algorithm. PRSJournal September 2007 DIO:10.1097/01/prs0000270303.44219.76.
7. Newcomb, W.; Heniford, T, et al . Long-term Outcomes After Abdominal Wall Reconstruction With Acellular Human Dermis in Patients With Abdominal Injuries. 2007 AAST Session IV, Poster #10