SYMPLICITY™ BLOOD PRESSURE PROCEDURE
About the Symplicity™ procedure
The Symplicity™ blood pressure procedure is a minimally invasive hypertension treatment that complements lifestyle changes and medications to help reduce blood pressure.1
Treatment options for high blood pressure
For a long time, the only way to treat high blood pressure, also known as hypertension, was through lifestyle changes, like diet and exercise, and by taking antihypertensive medications. Today, there is an innovative procedure that complements typical treatments — the Symplicity™ blood pressure procedure.
The procedure, explained.
Watch this short video to understand how the Symplicity™ blood pressure procedure works.
-16.7
mmHg
blood pressure reduction at three years.9
- The Symplicity blood pressure procedure may reduce high blood pressure,3-5 which is shown to lower your risk of serious health problems.6
- The effects of the Symplicity™ procedure keep working 24 hours a day – like a pill you never have to remember to take.3,4
- Clinical trial results show no impact to kidney function.†,7
- More than 30,000 people worldwide have received it.8
Reducing blood pressure by 10 mmHg can lower your risk of 10:
heart failure
↓28%
cardiovascular events
↓20%
stroke
↓27%
Not every person will experience the same results. Talk your doctor to see if the Symplicity blood pressure procedure is right for you. Your doctor should discuss all potential benefits and risks with you.
Frequently asked questions
Get answers to common questions about the Symplicity™ blood pressure procedure.
† Clinical trial results on participants three years after receiving this procedure showed no negative effects on their kidney function.
1. Medtronic Symplicity Spyral™ multi-electrode renal denervation catheter instructions for use. Medtronic; 2023.
2. Coates P, Tunev S, Trudel J, Hettrick DA. Time, temperature, power, and impedance considerations for radiofrequency catheter renal denervation. Cardiovasc Revasc Med. 2022;42:171–177. doi: 10.1016/j.carrev.2022.02.018.
3. Kandzari DE, Townsend RR, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medications. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.
4. Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451. doi: 10.1016/S0140-6736(20)30554-7.
5. Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022 ;399(10333) :1401-1410.
6. Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. The Lancet. 2016;387:957-67.
7. Schlaich M, Mahfoud F, Williams B, et al. Long-term safety and efficacy of renal denervation with the Symplicity Spyral catheter in the Global SYMPLICITY Registry. Oral presentation at: American Society of Nephrology Kidney Week; November 2021; San Diego, CA.
8. Medtronic data on file. RDN catheter historical data. February 2025. Data include both Symplicity™ Flex and Symplicity Spyral™.
9. Mahfoud F. Presented at EuroPCR 2023. Includes Symplicity Spyral™ ad Flex™ catheters.
10. Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387(10022):957–967. doi: 10.1016/S0140-6736(15)01225-8.