Pulsed field ablation (PFA) clinical evidence

Sphere-9™ catheter clinical evidence

The Sphere-9™ catheter is supported by a robust body of clinical evidence. Stay up-to-date on the latest information supporting the dual-energy catheter.


SPHERE Per-AF IDE trial

SPHERE Per-AF was a randomized trial of patients with atrial fibrillation comparing the Sphere-9™ catheter with the Affera™ mapping and ablation system to the THERMOCOOL SMARTTOUCH™* SF catheter with the CARTO™* 3 system.



PULSED AF trial

PULSED AF evaluated the safety and effectiveness of the PulseSelect™ PFA system for the treatment of patients with paroxysmal (PAF) or persistent (PsAF) atrial fibrillation.


Cryoablation clinical evidence

STOP AF First trial

View data from the clinical trial assessing initial rhythm control of paroxysmal AF with cryoballoon ablation versus antiarrhythmic drugs.


ICY-AVNRT trial

This trial assessed the use of the Freezor™ Xtra cardiac cryoablation catheter in treating atrioventricular nodal reentrant tachycardia (AVNRT).



STOP AF trial

Learn more about this randomized study on the effectiveness of the Arctic Front™ and Arctic Front Advance™ cardiac cryoablation catheters.


Fire and Ice trial

Discover information on this 1:1 randomized, noninferiority study comparing cryoballoon and radiofrequency ablation.


STOP Persistent AF trial

View information on this clinical trial assessing the safety and efficacy of the Medtronic cryoballoon in treating persistent AF patients.