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Living with atrial fibrillation (Afib)? Don't let Afib slow you down. Learn more about your treatment options and get back to living life — your way.


The STOP Persistent AF trial was the first and largest FDA-regulated, prospective, multicenter, single-arm clinical trial to assess the safety and efficacy for treating symptomatic persistent Afib patients who have failed drug treatment using the Arctic Front Advance™ Cryoballoon. The trial included 165 patients treated at 25 sites across the United States, Canada, and Japan. FDA approval was based on 150 patients treated in the United States.

The Arctic Front Advance Cardiac Cryoablation Catheter is indicated for the treatment of drug refractory recurrent symptomatic paroxysmal and persistent atrial fibrillation (episode duration less than 6 months).

Treatment with the cryoballoon was proven to be safe and effective.

Medtronic Cryoballoon on a blue background

Arctic Front Advance Pro Cryoballoon

Significant improvements in quality of life

The study demonstrated that patients experienced a significant improvement in their quality of life and Afib-related symptoms and a reduction in antiarrhythmic drug use after cryoablation. The graph below reflects data from the entire 165-patient population from the study.

Drastically reduced need for repeat ablations

Of the entire 165 patients treated in the study, 86.8% of patients did not require a repeat ablation.1

A quality of life graph from the STOP Persistent AF Clinical trial that shows that study patients atrial fibrillation symptoms were greatly reduced after receiving a cryoablation

I have Afib. Now what?

Were you or a loved one recently diagnosed with Afib? An Afib diagnosis can be overwhelming and comes with a lot of questions — causes, symptoms, treatment options, etc. Learn more about Afib and what you can do to take back your life.

Learn About Afib
Play Video This will play a video - What is atrial fibrillation?

Watch this video to learn more about the symptoms and treatment options for Afib.

Catheter Ablation For Atrial Fibrillation

Discover more about this procedure for treating atrial fibrillation (Afib) and what to expect during the recovery period.

Learn More
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Watch as Dennis Compton discusses his journey with persistent atrial fibrillation

Do you have Atrial Fibrillation?

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How do I Manage My Afib?

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Get treatment for your Afib. Enter your ZIP Code below to find a cryoballoon specialist near you. 

Have Questions?

It is important for you to get the right answers to your questions about your procedure. Talk to your doctor if you have questions, or contact Medtronic Patient Services.

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Information on this site should not be used as a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.



Su WW, Reddy VY, Bhasin K, et al. Cryoballoon Ablation of Pulmonary Veins for Persistent Atrial Fibrillation: Results From the Multicenter STOP Persistent AF Trial. Heart Rhythm. Published online June 23, 2020.