VENOUS LEG ULCERS — A  CLINICAL CHALLENGE

1 MILLION

people in the U.S. are affected by venous leg ulcers (VLU)<sup>1,2

Pie chart showing leg ulcer origins

70-90%

of all lower extremity ulcers are venous<sup>1,2</sup>

> 50%

of treated VLUs are recurrent ulcerations<sup>3</sup>

Graphic showing a venous leg ulcer

MAKE THE CONNECTION

Superficial venous reflux is usually present in patients with VLUs ― yet many go unassessed or untreated.1,4-6

CVI Diagnosis & Guidelines

Quality of Life Impact

Due to pain, mobility limitations, and other consequences, VLUs have a significant impact on patients.7-9

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INCREASED

RATES OF <br> DEPRESSION

DECREASED

QUALITY

OF LIFE

EARLY ENDOVENOUS ABLATION

TREATMENT MATTERS<sup>5

See Evra Study Results

Man and woman sitting on rock

32%

faster ulcer healing

time in the early

treatment group<sup>5</sup>

EXPERIENCE OUR CVI PORTFOLIO ADVANTAGE

Our comprehensive CVI toolkit empowers you to select the best approach for each patient.

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References

1

O’Donnell TF Jr, Passman MA, Marston WA, et al. Management of venous leg ulcers: Clinical Practice Guidelines of the Society for Vascular Surgery® and the American Venous Forum. J Vasc Surg. August 2014;60(2 Suppl):3S-59S.

2

Rice JB, Desai U, Cummings AK, Birnbaum HG, Skornicki M, Parsons N. Burden of venous leg ulcers in the United States. J Med Econ. May 2014;17(5):347-356.

3

Outpatient Wound Clinic Market Performance Report. Net Health Analytics. October 2013.

4

Adam DJ, Naik J, Hartshorne T, Bello M, London NJ. The diagnosis and management of 689 chronic leg ulcers in a single-visit assessment clinic. Eur J Vasc Endovasc Surg. May 2003;25(5):462-468.

5

Gohel MS, Heatley F, Liu X, et al. A Randomized Trial of Early Endovenous Ablation in Venous Ulceration. N Engl J Med. May 31, 2018;378(22)2105-2114.

6

Devlin NJ, Shah KK, Feng Y, Mulhern B, van Hout B. Valuing health-related quality of life: An EQ-5D-5L value set for England. Health Econ. January 2018;27(1):7-22.

7

Valencia IC, Falabella A, Kirsner RS, Eaglstein WH. Chronic venous insufficiency and venous leg ulceration. J Am Acad Dermatol. March 2001;44(3):401-421.

8

Phillips T, Stanton B, Provan A, Lew R. A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications. J Am Acad Dermatol. July 1994;31(1):49-53.

9

Green J, Jester R. Health-related quality of life and chronic venous leg ulceration: part 1. Br J Community Nurs. December 2009;14(12):S12,S14,S16-17.