Your browser is out of date
With an updated browser, you will have a better Medtronic website experience. Update my browser now.
CAUTION: The Intrepid™ Transcatheter Mitral Valve Replacement System is an investigational device. Limited by federal (United States) law to investigational use. Exclusively for clinical investigations. Not approved by FDA and not for sale in the United States.
The Intrepid Transcatheter Mitral Valve Replacement System (TMVR) integrates self-expanding stent technology with a tissue heart valve to facilitate minimally invasive, catheter-based implantation.
The prosthesis is compressed inside a hollow delivery catheter and implantation is completed through either transapical (TA) or transfemoral (TF) access. It is designed to engage and conform to the native annulus without need for additional sutures, tethers, or anchors.
The device design features:
Read through the inclusion/exclusion criteria and view more resources to help you determine if you have patients who are eligible to participate in the trial.
Send an Email
Use the button below to send an email to your colleagues about the trial. This email template is prepopulated with basic information about the trial and a link to the website where your colleagues can learn more.
Share the study
U.S. Census Bureau. Statistical Abstract of the U.S.: 2006, Table 12.
Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: a population-based study. Lancet. September 16, 2006;368(9540):1005-1011.
Abramowitz Y, Jilaihawa H, Chakravarty T, Mack MJ, Makkar RR. Mitral Annulus Calcification. J Am Coll Cardiol. October 27, 2015;66(17):1934-1941.
Vergeer M, Cohn DM, Boekholdt SM, et al. Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT. Atherosclerosis. August 2010;211(2):558-564.
Barasch E, Gottdiener JS, Marino Larsen EK, Chaves PHM, Newman AB, Manolio TA. Clinical significance of calcification of the fibrous skeleton of the heart and aortosclerosis in community dwelling elderly. The Cardiovascular Health Study (CHS). Am Heart J. January 2006;151(1):39-47.
Fox CS, Vasan RS, Parise H, et al. Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study. Circulation. March 25, 2003;107(11):1492-1506.
Bedeir K, Kaneko T, Aranki S. Current and evolving strategies in the management of severe mitral annular calcification. J Thorac Cardiovasc Surg. February 2019;157(2):555-566.
Kaneko T, Hirji S, Percy E, et al. Characterizing Risks Associated With Mitral Annular Calcification in Mitral Valve Replacement. Ann Thorac Surg. December 2019;108(6):1761-1767.