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To evaluate the safety and effectiveness of TYRX™ Absorbable Antibacterial Envelope in reducing the risk of CIED (cardiac implantable electronic device) infection.
The TYRX WRAP-IT Study shows a significant reduction of CIED infections with the use of TYRX Absorbable Antibacterial Envelope.
Major CIED Infection Rate (%)
Major CIED Pocket Infection Rate (%)
75% of initial major CIED infections in the study were pocket infections.
Complication Rate (%)
CIED revision, generator replacement, upgrade, or de novo CRT-D.
Primary endpoint included CIED infections requiring system extraction or revision, long-term antibiotic therapy with infection recurrence, or death within 12 months of the CIED procedure.
Procedure- and system-related complications through 12 months.
Tarakji KG, Mittal S, Kennergren C, et al. Antibacterial Envelope to Prevent Cardiac Implantable Device Infection. N Engl J Med. May 16, 2019;380(20):1895-1905.