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The Mosaic™ bioprosthesis is an evolution in durability and implantability, based on the proven platform of the Hancock™ II valve.
Download product brochureThe Mosaic bioprosthesis — based on more than 30 years of Medtronic tissue-valve design expertise — is a great option for surgeons seeking exceptional long-term durability, excellent hemodynamics, and a smooth implanting experience.
Published clinical experience demonstrates impressive long-term performance, including in patients under 60 years. Additional factors that may contribute to durability are:
† The benefits of AOA tissue treatment have been demonstrated through animal testing. No direct clinical evaluation of the benefits of AOA treatment in humans has been conducted.
In a prospective, multicenter, long-term follow-up observational study of 1,029 patients, the following outcomes were reported:
Adverse events potentially associated with the use of bioprosthetic heart valves include: angina, cardiac arrhythmia, cardiac dysrhythmias, endocarditis, heart failure, hemolysis, hemolytic anemia, hemorrhage (anticoagulant/antiplatelet related), leak (transvalvular or paravalvular), myocardial infarction nonstructural dysfunction (obstructive pannus ingrowth, suture dehiscence, inappropriate sizing, other), stroke, structural deterioration (calcification, leaflet tear, other) thromboembolism, valve thrombosis. It is possible that these complications could lead to reoperation, explantation, permanent disability, and death.
As reported in the Mosaic bioprostheis Instructions for Use.
Mosaic mitral size3 |
25 |
27 |
29 |
31 |
33 |
---|---|---|---|---|---|
Mean gradient (mm) (n = ) |
5.7 ± 1.7 (41) |
4.6 ± 2.1 (98) |
4.4 ± 1.8 (123) |
3.7 ± 1.4 (50) |
3.4 ± 1.8 (8) |
Mean EOA (cm2) (n = ) |
1.6 ± 0.4 (35) |
1.7 ± 0.5 (90) |
1.8 ± 0.5 (114) |
1.7 ± 0.5 (43) |
1.9 ± 0.5 (6) |
The Mosaic valve reflects the asymmetry of the native porcine valve. The largest leaflet of the Mosaic is intended to align with the patient's anterior mitral leaflet to accommodate ventricular flow.
Mosaic 29
The asymmetrical design of Mosaic offers one wider leaflet spaced at 135° with an interstrut distance of 18.4 mm.
Viewed from the inflow aspect, the widest intercommissural space of the Mosaic lies between the green suture marker and the first commissure post in the counterclockwise direction. Orienting the bioprosthesis in the annulus such that the green suture marker is directed approximately toward the right fibrous trigone should position the widest intercommissural space appropriately.
Valve dimensions and geometry facilitate future ViV procedures.
Sapien™* device deployed inside Mosaic mitral
Image source: Mitral valve-in-valve app.
The Cinch™ implant system capitalizes on the flexible stent to facilitate valve implantation, particularly through tight patient anatomy:
Order |
Valve size |
Orifice |
Suture ring |
Valve height |
Ventricular protrusion (± 0.5 mm) |
---|---|---|---|---|---|
|
(A) |
(B) |
(C) |
(D) |
(E) |
310C25 |
25 |
22.5 |
33.0 |
18.0 |
13.5 |
310C27 |
27 |
24.0 |
35.0 |
19.0 |
14.0 |
310C29 |
29 |
26.0 |
38.0 |
20.5 |
15.5 |
310C31 |
31 |
28.0 |
41.0 |
22.0 |
17.0 |
310C33 |
33 |
30.0 |
43.0 |
23.0 |
17.5 |
Order |
Valve size |
Orifice diameter |
Suture ring |
Valve |
Aortic |
---|---|---|---|---|---|
|
(A) |
(B) |
(C) |
(D) |
(E) |
305C219 |
19 |
17.5 |
25.0 |
13.5 |
11.0 |
305C221 |
21 |
18.5 |
27.0 |
15.0 |
12.0 |
305C223 |
23 |
20.5 |
30.0 |
16.0 |
13.5 |
305C225 |
25 |
22.5 |
33.0 |
17.5 |
15.0 |
305C227 |
27 |
24.0 |
36.0 |
18.5 |
15.5 |
305C229 |
29 |
26.0 |
39.0 |
20.0 |
16.0 |
Order |
Valve size |
Orifice |
Suture ring |
Valve height |
Aortic |
---|---|---|---|---|---|
|
(A) |
(B) |
(C) |
(D) |
(E) |
305U219 |
19 |
17.5 |
24.0 |
13.5 |
11.0 |
305U221 |
21 |
18.5 |
26.0 |
15.0 |
12.0 |
305U223 |
23 |
20.5 |
28.0 |
16.0 |
13.5 |
305U225 |
25 |
22.5 |
30.0 |
17.5 |
15.0 |
305U227 |
27 |
24.0 |
32.0 |
18.5 |
15.5 |
305U229 |
29 |
26.0 |
34.0 |
20.0 |
16.0 |
‡ Equivalent to annulus diameter.
Order number |
Description |
---|---|
T7308C |
Mosaic aortic sizers tray |
T7615MSM |
Tray, accessory, Mosaic mitral |
T7308U |
Tray, accessory, Mosaic Ultra aortic |
7308U |
Mosaic Ultra aortic sizers |
7639 |
Handle (234 mm length) pliant, without locknut to be used with Mosaic or Mosaic Ultra prostheses |
7639XL |
Handle (368 mm length) pliant, without locknut to be used with Mosaic or Mosaic Ultra prostheses |
7308C |
Mosaic aortic sizer set |
7310 |
Mosaic mitral obturator set (no handles, no tray) |
Training, education, and collaboration on the treatment of mitral and tricuspid valve disease.
Register here™*Third-party brands are trademarks of their respective owners.
Rieß FC, Fradet G, Lavoie A, Legget M. Long-Term Outcomes of the Mosaic Bioprosthesis. Ann Thorac Surg. March 2018;105(3):763-769.
Mosaic Porcine Bioprosthesis. Instructions for Use. Medtronic, Inc. 2018. 1220016001 Rev. 1C.
Beute T, Goehler M, Parker J, et al. Long-Term Outcomes of Mosaic versus Perimount Mitral Replacements: 17-Year Follow Up of 940 Implants. Ann Thorac Surg. August 2020;110(2):508-515.