SynchroMed™ III Implantable infusion system

SynchroMed™ III is an implantable drug delivery system that helps manage chronic pain, cancer pain, and severe spasticity.

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Simple, safe, and effective intrathecal therapy

Unlike medications that must be absorbed systemically and must cross the blood-brain barrier to reach the receptors on the spinal cord to be effective, an implanted SynchroMed™ III programmable pump and catheter deliver prescribed amounts of medication directly into the cerebrospinal fluid in the intrathecal space bypassing the blood-brain barrier.

Targeted drug delivery (TDD) into the intrathecal space offers effective relief at a fraction of the systemic dose, which can reduce side effects.1-4

Targeted Drug Delivery Compared to Systemic Delivery with Oral Medication

Product details

SynchroMed™ III pump

This system features a new REFILL ONLY physician workflow for more efficient programming, additional protections for patient data through enhanced cybersecurity, and improved electronics capable of delivering firmware upgrades to implanted devices going forward.

Together, these enchantments within the SynchroMed™ III system offer a enhanced platform compared to use of the SynchroMed™ II system.

Synchromed III

Allows full-body 1.5 and 3T MRI scans under specific conditions

Redesigned for peace of mind

SynchroMed™ III continues to provide peace of mind with proven durable design enhancements built in.

battery coating

Battery coating


Gear wheel 3 material change

TDD feedthrough image

Feedthroughs encapsulated

DLC coating

Diamond-like carbon (DLC) coating added

Ascenda™ catheter

  • Available in two lengths
  • Flexible construction with the ability to trim to the desired length
  • Unique four-layer construction for compression resistance
  • Sutureless connector
Close up of the Ascenda catheter.

Compatible products

SynchroMed™ Clinician Programmer

The SynchroMed™ clinician programmer provides a simple, guided workflow approach to programming SynchroMed™ implantable pumps.

myPTM™ Personal Therapy Manager

The myPTM™ personal therapy manager works with the SynchroMed™ pump to help alleviate unpredictable pain by enabling on-demand intrathecal boluses.

Efficio™ Management Software

The Efficio™ management software is designed to simplify your pump practice by offering efficient schedule planning, simple drug tracking, historical dosing insights, and on-demand access to reports.

SynchroMed™ III targeted drug infusion system

Ordering information

Item Description
SynchroMed™ III pump (8667-20 and 8667-40)  SynchroMed™ III pump with 20 mL and 40 mL reservoir capacities, both redesigned with new electronics and firmware to enhance cybersecurity and enable upgradability.
SynchroMed™ Clinician Programmer CT900 tablet with A810 software v2.x  Clinician programmer with new refill-only workflow that streamlines clinician programming. 
TH90T01 myPTM™ Personal Therapy Manager with A820 software v2.x  myPTM™ Personal Therapy Manager with updates to clarify clinician restrictions for patient bolus activation.

Product portfolio

Medtronic has a decades-long history of creating implantable drug delivery system for pain relief.

Education & training

Learn more about targeted drug therapy for chronic pain.

Clinical evidence

See the results of our ongoing commitment to research.

† MR Safety Triangle Under specific conditions. Refer to product labeling for full list of conditions:

‡ Source: 2022 TDD Product Performance Report


Hamza, M et al. Prospective Study of 3-Year Follow-Up of Low-Dose Intrathecal Opioids in the Management of Chronic Nonmalignant Pain. Pain Medicine. (United States) 13, 1304–1313 (2012).


Smith, TJ et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: Impact on pain, drug-related toxicity, and survival. Journal of Clinical Oncology. 20, 4040–4049 (2002).


Rushton, DN. Upper Motor Neurone Syndrome and Spasticity: Chapter 10 Intrathecal Baclofen for the Control of Spinal and Supraspinal Spasticity. ed. Barnes, MP and Johnson, GR pages 181–192. (Cambridge University Press, 2008). doi:10.1017/cbo9780511544866.011.


Deer, T et al. Intrathecal drug delivery for treatment of chronic low back pain: Report from the National Outcomes Registry for Low Back Pain. Pain Medicine. 5, 6–13 (2004).