The AdaptivCRT™ Algorithm Optimizes CRT Pacing Every Minute Whether AV Conduction Is Normal, Prolonged, or Blocked
It adapts to meet the constantly changing needs of CRT patients because it responds to what he or she is doing and automatically decides when and how to pace the heart.
The AdaptivCRT Algorithm has two different modes:
For more information on the AdaptivCRT Algorithm feature go to: https://www.medtronicacademy.com/features/adaptivcrt-feature
The AdaptivCRT Algorithm is associated with a 31% relative reduction in mortality1 (after adjusting for other potential risk factors*)
1,835 patients with a CRT system were enrolled in the Medtronic Product Surveillance Registry. We compared patients with AdaptivCRT on versus off to evaluate mortality status between the two groups. Frailty survival models were used to evaluate the potential survival benefit of the algorithm, adjusting for patient heterogeneity and center variability.
Patients who received AdaptivCRT were associated with a 31% relative reduction in all-cause mortality versus conventional CRT (after adjusting for other potential risk factors*).
Total Survival AdaptivCRT vs. Standard CRT
Age, gender, LVEF, NYHA Class, QRS duration, AF, CAD, Hypertension, AV Block, and LBBB.
The AdaptivCRT Algorithm showed a 12% improvement in CRT response at 6 months*2
To examine whether synchronized left ventricular pacing resulted in better outcomes
In patients with normal AV conduction, the AdaptivCRT Algorithm provided mostly Synchronized LV Pacing and demonstrated better clinical outcomes compared to echocardiography-optimized Biventricular pacing
Clinical Composite Score is a composite measure of mortality, HF hospitalizations, and symptomatic changes.
The AdaptivCRT Algorithm showed a 46% reduction in AF risk*3
To compare the long-term effects of AdaptivCRT with conventional cardiac resynchronization (convCRT) therapy pacing on the incidence of AF
Patients with AdaptivCRT had a reduced risk of AF compared with those receiving conventional CRT*
Incidence of Primary End Point
(≥48 consecutive hours of atrial tachycardia/atrial fibrillation)
Most of the reduction in AF occurred in subgroups with prolonged AV conduction at baseline and with significant left atrial reverse remodeling.
The AdaptivCRT Algorithm showed a 35% reduction in AF risk4
44,838 patients in the Medtronic CareLink™ database were compared for the risk of incident continuous AF > 48 hours based on the programmed use of AdaptivCRT versus standard BiV pacing.
Incidence of Atrial Fibrillation
Kaplan-Meier methods and the log-rank test were used to compare groups’ time to first occurrence of 48 hours of AF. 48 hours of AF was defined to be 2 consecutive days of > 23 hours of AF as measured by the device.
The AdaptivCRT Algorithm showed a 59% reduction in a patient’s odds of a 30-day HF readmission5
To investigate the impact of the Medtronic AdaptivCRT algorithm on 30-day readmissions after heart failure and all-cause index hospitalizations
Use of AdaptivCRT is associated with a significant reduction in the probability of HF readmissions after both HF and all-cause hospitalizations
Kaplan-Meier Curves of Hospital Readmissions
Singh JP, et al. Improved Survival With Dynamic Optimization Of CRT Pacing Using AdaptivCRT Algorithm: Analysis Of Real-world Patient Data. Presented at HRS 2018 (Abstract B-AB37 -06).
Birnie D, et al. Heart Rhythm. 2013;10:1368-1374.
Birnie D, et al. Heart Rhythm. 2017;14:1820-1825.
Hsu J, et al. Heart Rhythm. 2017;14:S86
Starling RC, et al. JACC Heart Fail. 2015;3:565-572.