The Impact of Sudden Cardiac Arrest 

 SCA is the abrupt loss of heart function, breathing, and consciousness resulting from an electrical disturbance in the heart. Conditions such as tachycardia have an increased risk for SCA.

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 356,000 

The number of out-of-hospital cardiac arrests annually in the United States — nearly 90% of them are fatal.3

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~5%

The estimated national out-of-hospital survival-to-discharge rate for EMS-assessed SCA.4

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1 Life Every 2 Minutes

SCA claims one life every 2 minutes, taking more lives each year than breast cancer, lung cancer, or AIDS.5,6

Improve Patient Survival*

Guideline-directed medication therapy (GDMT) can help to reduce the risk of SCA, but medication alone is often not enough.1 Although medication can lower the risk of an SCA event, once a patient has an event, only a defibrillator can restart the heart.1

Why an ICD?

Data analysis from prior and contemporary studies on ICD therapy effectiveness 

Presented by
Gianluigi Savarese, M.D., Ph.D.
Medtronic Global Grand Rounds
February 2020

Clinical Evidence 

ICD and CRT-D therapies have been widely studied to show a significant improvement in all-cause mortality.

CRT and ICD Evidence

Chart showing ICD and CRT studies done between 2011 and 2021.

Results are from different studies and are shown for illustrative purposes only. Study sizes, designs, and populations vary.

SCD-HeFT†1
Single Chamber ICD All-cause Mortality

Graph showing a 23% relative reduction in all-cause mortality shown in the SCD-HeFT study

n = 1,676, 45.5 months median follow-up (p = 0.007)

  The study demonstrated a 5% rate of acute device-related complications and 9% rate of chronic complications.

SwedeHF Analysis, 2019‡7 
ICD All-cause Mortality

Graph showing a 27% relative reduction in all-cause mortality shown in the SWEDE-HF study

n = 2,610, 1 year, propensity score matched analysis (p < 0.01)

  Complications have occurred in 5% of the patients at the time of implantation and in 9% later in the course of the trial.

Help Increase Patient Access 

ICD therapy is underutilized overall, and even more so with women and patients in underserved communities.2 By understanding our biases, together we can reverse these trends and give all patients access to lifesaving therapy.

    Patients with New ICD/CRT-D Indication, 2012–20162

Graph showing that 12.7% of indicated women received an ICD or CRT-D versus the 16.7% of indicated men from 2012 to 2016

Why Might ICD Therapy Be Underutilized?

Data findings in ICD underutilization and disparities in care among populations

Presented by
Sana Al-Khatib, M.D., M.H.S.
Medtronic Global Grand Rounds
February 2020

Male-focused Studies

Current guidelines are based on trials where ~80% of the patients were men.8

Profile Differences

Device Counseling

Differing Symptoms

Differences in how symptoms are communicated can affect course of treatment.11

Know Who Can Benefit 

Feel confident knowing which patients could benefit from an ICD. Know the numbers and consider these factors when assessing your patients.*12

Who Can Benefit from ICD Therapy?

Overview of the DANISH Study and putting results in perspective for nonischemic patients 

Presented by
Michael Gold, M.D., Ph.D., FHRS
Medtronic Global Grand Rounds
February 2020

2017 AHA/ACC/HRS Guidelines for Implantable Defibrillators12: Class I Recommendations

Download this chart to quickly refer to the indications for ICD therapy for primary and secondary prevention. Patients should already be on optimized medical therapy and have a meaningful survival for at least 1 year.

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Our Solutions

We offer a full line of ICDs and services for treating your patients at risk for SCA, including ICD leads and the nation’s leading remote monitoring service, the Medtronic CareLink™ network.13

Educate Your Patients 

Download conversation tools to explain the benefits of ICD therapy.

SCA Patient Brochure

Ask the  ICD.com

Answers to all the questions your patients never knew they had about ICDs

Ask the ICD

Therapy Awareness Programs 

We’ll work with your clinic or medical center to provide presentations, data, and resources to support your staff’s understanding of lifesaving device therapies.

Download Brochure

Educational Resources on Medtronic Academy

Courses to increase your understanding of ICDs

Visit Medtronic Academy
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Our ICD Systems

Our full line of ICDs and defibrillator leads

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Attain Stability Quad and Sprint Quattro leads on a light blue background

Our ICD Features

Unique features to tailor therapy for your patients' needs

Explore Features
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Managing Your Patients

Tools to keep you and your patients connected

Monitoring Options
*

Major clinical studies and registries demonstrated a 5% rate of acute device-related complications and 9% rate of chronic complications with ICD therapy.

The study demonstrated a 5% rate of acute device related complications and 9% rate of chronic complications.

Complications have occurred in 5% of the patients at the time of implantation and in 9% later in the course of the trial.

References

1

Bardy GH, Lee KL, Mark DB, et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. January 20,
2005;352 (3):225-237.

2

Curtis AB, et al. Improving Heart Failure Outcomes Across the Care Continuum. Presented at HRS 2019; San Francisco, CA.

3

Benjamin EJ, Virani SS, Callaway CW, et al. Heart Disease and Stroke Statistics — 2018 Update: A Report From the American Heart Association. Circulation. March 20, 2018;137(12):e67-e492.

4

Daya M, Schmicker R, May S, Morrison L. Current burden of cardiac arrest in the United States: Report from the Resuscitation Outcomes Consortium. Paper commissioned by the Committee on the Treatment of Cardiac Arrest: Current Status and Future Directions. June 30, 2015. 

5

Sudden Cardiac Arrest (SCA). Heart Rhythm Society. Available at https://upbeat.org/heart-rhythm-disorders/sudden-cardiac-arrest. Accessed November 5, 2020. 

6

Myerburg RJ, Junttila MJ. Sudden cardiac death caused by coronary heart disease. Circulation. February 28, 2012;125(8):1043-1052.

7

Schrage B, Uijl A, Benson L, et al. Association Between Use of Primary-Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients With Heart Failure. Circulation. November 5, 2019;140(19):1530-1539.

8

Zusterzeel R, Selzman K, Sanders WE, et al. Cardiac resynchronization therapy in women: US Food and Drug Administration meta-analysis of patient-level data. JAMA Intern Med. August 2014;174(8):1340-1348.

9

Lenzen MJ, Rosengren A, Scholte op Reimer WJ, et al. Management of patients with heart failure in clinical practice: Differences between men and women. Heart. March 2008;94(3):e10.

10

Hess PL, Hernandez AF, Bhatt DL, et al. Sex and Race/Ethnicity Differences in Implantable Cardioverter-Defibrillator Counseling and Use Among Patients Hospitalized With Heart Failure. Circulation. August 16, 2016;134(7):517-526.

11

Women in EP Working Group Meeting. HRS 2019. Data on file.

12

Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. September 25, 2018;138(13):e210-e271.

13

Devices supported on the CareLink network. January 2014. Data on file.