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The VenaSeal procedure delivers a small amount of a specially formulated medical adhesive to seal — or close — the diseased vein, rerouting blood to nearby healthy veins and providing symptom relief. The VenaSeal closure system is a safe and effective treatment, offering significant improvement in quality of life.1-4
A specially formulated medical adhesive is placed in the diseased vein via a small catheter.
Light external pressure is applied to adhere the vein walls together. This step is repeated for the length of the vein.
The catheter is removed and a single adhesive bandage is applied to the vein access site.
I had all the signs and symptoms — tired legs, restless leg syndrome, achiness, the unsightly bulges. The treatment went very, very smoothly. I was very comfortable. I would suggest it to anybody.– Heather A., VenaSeal patient
You will have an ultrasound imaging exam of the leg being treated. This exam is important for assessing the diseased superficial vein and planning the procedure.
Your doctor can discuss the procedure with you. Here is a brief summary of what to expect:
Individual results may vary. Images courtesy of Dr. Kathleen Gibson.
The VenaSeal procedure went very smoothly; there was no pain involved.— Heather A., VenaSeal patient
My leg heaviness is gone, and I can walk 18 holes of golf again.— Steve H., VenaSeal patient
Adverse events can include allergic reaction, inflammation, phlebitis, deep vein thrombosis, and/or pulmonary embolism.
Type of therapy
Closure with medical adhesive (permanent implant)
Inpatient or outpatient procedure
One- versus two-leg treatment
Typically, both legs can be treated in the same appointment
Needle sticks required
One needle stick for vein access
Typical post-treatment recovery
Typically limited to healing of vein access site; some patients may experience temporary skin and tissue irritation
Not required, but your doctor may recommend it post-procedure
Procedure success rate
94.6% closure rate at five years1
Most patients feel little, if any, pain during the outpatient procedure.1
The VenaSeal procedure is designed to reduce recovery time. Many patients return to normal activity immediately after the procedure. Your doctor can help you determine when you can return to normal activity.
Symptoms are caused by the diseased superficial vein. Thus, symptoms may improve as soon as the diseased vein is closed.
While bruising is common with all vein treatments, patients report it to be mild and to resolve with no treatment or with over-the-counter anti-inflammatory medication.1
Only a very small amount of VenaSeal procedure adhesive is used to close the vein. Your body will naturally create scar tissue around the adhesive over time to keep the vessel permanently closed.
The VenaSeal procedure uses an adhesive to close the superficial vein. This differs from thermal energy procedures that use heat to close the vein. This intense heat requires numbing medicine, which is injected through multiple needle sticks. The injections may cause pain and bruising after the procedure.
As with any procedure, insurance coverage may vary. Insurance companies detail access to the VenaSeal procedure and other nonthermal ablation procedures in coverage policies for varicose veins or chronic venous insufficiency. Please reach out to your insurance company to discuss your specific plan coverage and potential costs prior to seeking treatment.
Morrison N, Gibson K, McEnroe S, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. April 2015;61(4):985-994.
Proebstle T, Alm J, Dimitri S, et al. Three-year follow-up results of the prospective European Multicenter Cohort Study on Cyanoacrylate Embolization for treatment of refluxing great saphenous veins. J Vasc Surg Venous Lymphat Disord. March 2021;9(2):329-334.
Almeida JI, Javier JJ, Mackay EG, Bautista C, Cher DJ, Proebstle TM. Thirty-sixth-month follow-up of first-in-human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. September 2017;5(5):658-666.
Morrison N, Gibson, Vasquez M, et al. VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. May 2017;5(3):321-330.
Information on this site should not be used as a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.