The VenaSeal procedure delivers a small amount of a specially formulated medical adhesive to seal — or close — the diseased vein, rerouting blood to nearby healthy veins and providing symptom relief. The VenaSeal closure system is a safe and effective treatment, offering significant improvement in quality of life.1-4

Using an ultrasound, your doctor will position a catheter into the diseased vein through a small access site.
Illustration showing how a catheter is placed in the vein during a VenaSeal procedure

A specially formulated medical adhesive is placed in the diseased vein via a small catheter.

Illustration of VenaSeal adhesive being placed in the vein through a small catheter

Light external pressure is applied to adhere the vein walls together. This step is repeated for the length of the vein.

Clinician's hand compressing a vein after a drop of VenaSeal medical adhesive has been inserted

The catheter is removed and a single adhesive bandage is applied to the vein access site.

Illustration of small catheter being removed from the vein after a VenaSeal procedure
VenaSeal patient Heather jogging on grass

I had all the signs and symptoms — tired legs, restless leg syndrome, achiness, the unsightly bulges. The treatment went very, very smoothly. I was very comfortable. I would suggest it to anybody.

– Heather A., VenaSeal patient

You will have an ultrasound imaging exam of the leg being treated. This exam is important for assessing the diseased superficial vein and planning the procedure.

Your doctor can discuss the procedure with you. Here is a brief summary of what to expect:

  • You may feel some minor pain or stinging with a needle stick to numb the site where the doctor will access your vein. 
  • Once the area is numb, your doctor will insert the catheter (i.e., a small hollow tube) into your leg. You may feel some pressure from the placement of the catheter.
  • The catheter will be placed in specific areas along the diseased vein to deliver small amounts of the medical adhesive. You may feel a mild sensation of pulling. An ultrasound will be used during the procedure to guide and position the catheter.
  • After treatment, the catheter is removed and a small adhesive bandage is placed over the puncture site.
  • You will be taken to the recovery area to rest.
  • Your doctor will recommend follow-up care as needed.
Patient leg before VenaSeal procedure
Patient leg three months after VenaSeal procedure

Individual results may vary. Images courtesy of Dr. Kathleen Gibson.

The VenaSeal procedure went very smoothly; there was no pain involved.

— Heather A., VenaSeal patient

My leg heaviness is gone, and I can walk 18 holes of golf again.

— Steve H., VenaSeal patient
  • Simple outpatient procedure
  • Lasting results, with a 94.6% closure rate at five years1
  • Compression stockings may not be needed after the procedure2,3
  • Faster recovery time than thermal ablation1,2
  • Less pain and bruising than thermal ablation1,2
  • No tumescent anesthesia

Adverse events can include allergic reaction, inflammation, phlebitis, deep vein thrombosis, and/or pulmonary embolism.

Type of therapy
Closure with medical adhesive (permanent implant)

Inpatient or outpatient procedure
Outpatient procedure

One- versus two-leg treatment
Typically, both legs can be treated in the same appointment

Needle sticks required
One needle stick for vein access

Typical post-treatment recovery
Typically limited to healing of vein access site; some patients may experience temporary skin and tissue irritation

Compression hose
Not required, but your doctor may recommend it post-procedure

Procedure success rate
94.6% closure rate at five years1

Most patients feel little, if any, pain during the outpatient procedure.1

The VenaSeal procedure is designed to reduce recovery time. Many patients return to normal activity immediately after the procedure. Your doctor can help you determine when you can return to normal activity.

Symptoms are caused by the diseased superficial vein. Thus, symptoms may improve as soon as the diseased vein is closed.

While bruising is common with all vein treatments, patients report it to be mild and to resolve with no treatment or with over-the-counter anti-inflammatory medication.1

Only a very small amount of VenaSeal procedure adhesive is used to close the vein. Your body will naturally create scar tissue around the adhesive over time to keep the vessel permanently closed.

The VenaSeal procedure uses an adhesive to close the superficial vein. This differs from thermal energy procedures that use heat to close the vein. This intense heat requires numbing medicine, which is injected through multiple needle sticks. The injections may cause pain and bruising after the procedure.

As with any procedure, insurance coverage may vary. Insurance companies detail access to the VenaSeal procedure and other nonthermal ablation procedures in coverage policies for varicose veins or chronic venous insufficiency. Please reach out to your insurance company to discuss your specific plan coverage and potential costs prior to seeking treatment.

Find a vein disease doctor or clinic near you

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Morrison N, Gibson K, McEnroe S, et al. Randomized trial comparing cyanoacrylate embolization and radiofrequency ablation for incompetent great saphenous veins (VeClose). J Vasc Surg. April 2015;61(4):985-994.


Proebstle T, Alm J, Dimitri S, et al. Three-year follow-up results of the prospective European Multicenter Cohort Study on Cyanoacrylate Embolization for treatment of refluxing great saphenous veins. J Vasc Surg Venous Lymphat Disord. March 2021;9(2):329-334.


Almeida JI, Javier JJ, Mackay EG, Bautista C, Cher DJ, Proebstle TM. Thirty-sixth-month follow-up of first-in-human use of cyanoacrylate adhesive for treatment of saphenous vein incompetence. J Vasc Surg Venous Lymphat Disord. September 2017;5(5):658-666.


Morrison N, Gibson, Vasquez M, et al. VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins. J Vasc Surg Venous Lymphat Disord. May 2017;5(3):321-330.

Information on this site should not be used as a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.