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Take action on hypertension by building a dedicated program.

Test your knowledge

Hypertension (HTN) remains an urgent global health challenge. Do you know how many patients remain uncontrolled with current treatments?

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Find the right patients

Explore resources for identifying patients who could benefit from the Symplicity blood pressure procedure.

Explore data from multiple randomized controlled trials of Medtronic RDN.

Multiple randomized controlled trials

The Symplicity blood pressure procedure has demonstrated significant and safe blood pressure reductions in two pivotal, sham-controlled trials and a real-world registry with sustained blood pressure reductions through three years.1–3


Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet 2020;395:1444–14510.


Kandzari DE, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. The Lancet. 2018;391(10137):2346-2355.


Mahfoud F, Mancia G, Schmieder R, et al. Three-year safety and efficacy in the Global Symplicity Registry: Impact of antihypertensive medication burden on blood pressure reduction. Presented at PCR e-course 2020.