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PF ablation systems

PulseSelect™ pulsed field ablation system

<p>The PulseSelect™ pulsed field ablation (PFA) system combines predictable energy delivery, real-time contact feedback, and workflow adaptability.</p>

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Why the PulseSelect™ PFA system?

Proven safety

Engineered with safety features from over 15 years of electroporation research and supported by one of the safest AF ablation IDE trials to date and several independent studies2–18

Consistent efficiency

Rapid, effective PVI through consistent and predictable energy delivery and catheter maneuverability

Simplified adaptability

A plug-and-play PFA system designed to complement existing workflows with real-time tissue contact feedback seamlessly integrated into the PulseSelect™ generator display

What are electrophysiologists saying about the PulseSelect™ PFA catheter?

This is an icon of open quotes.

Compared to other ablation strategies, [the PulseSelect™ PFA system] is very cost-efficient, very time-efficient, and thus far, very effective. It has really streamlined the procedure, making it very quick, safe, and simple.”

– Jason Payne, MD, Cardiac Electrophysiologist, Omaha, NE

Smiling portrait of Jason Payne, MD, a cardiac electrophysiologist in Omaha, Nebraska.

Hear how cardiac electrophysiologists use the PulseSelect™ system, and how the PFA catheter delivers simplicity, safety, and efficiency with a zero exchange workflow.

Statements based on physician experience. Individual results vary. Physician is a paid consultant of Medtronic.

Clinical evidence for the PulseSelect™ PFA system

The PulseSelect™ PFA system is supported by evidence from the PULSED AF IDE trial and a growing body of independent real-world experience. Clinical studies have demonstrated strong safety outcomes,2–18 reproducible PVI durability,19–21 and sustained effectiveness across patients with paroxysmal and persistent AF.2

Clinical and real-world evidence

Key findings from the PULSED AF IDE trial and independent real-world studies demonstrate consistent safety and durable lesion formation across diverse EP workflows.

  • 0.7% safety event rate in the PULSED AF IDE trial2
  • 0.3% overall major complication rate across > 1,500 patients in 16 real-world studies†,3–18
  • > 95% pulmonary vein durability in three independent remapping studies‡,19–21
View clinical evidence compendium (open in new window)
Explore the PULSED AF IDE trial

PulseSelect™ PFA catheter features

Precision engineered for predictable energy delivery

The PulseSelect™ PFA catheter is designed to support predictable, consistent, and contiguous pulsed field energy delivery for PVI. Fixed electrode spacing, stable catheter positioning, and uniform tissue contact work together to support reproducible lesion formation.

This is an image of the PulseSelect™ pulsed field ablation catheter with callouts to highlight specific features.

Key catheter features

  1. 9 electrodes built to sense, ablate, and pace
  2. 25 mm diameter loop
  3. 9 Fr over-the-wire shaft with bidirectional steering
This is an image of the PulseSelect™ pulsed field ablation catheter tip.

Fixed electrode spacing to produce a reliable field for predictable and contiguous energy delivery

This is an image of the side of the PulseSelect™ pulsed field ablation catheter tip, showing the 20-degree forward tilt.

Twenty-degree forward tilt for consistent tissue contact

Real-time tissue contact feedback built into the generator display

The PulseSelect™ proximity indicator provides impedance-based tissue contact feedback designed specifically for the PulseSelect™ catheter. Real-time visualization of catheter-to-tissue proximity enables contact assessment without changing existing workflows.

Key proximity features

Progressive indicator display shows increasing tissue contact

Real-time response, single-electrode sensitivity

User-configurable proximity thresholds

Auto-baseline impedance for streamlined workflow

Built-in ablation counter

PulseSelect™ PFA generator features

  1. Integrated proximity indicator display for real-time tissue contact assessment
  2. Automatic overcurrent detection for safe energy delivery
  3. Optional R-wave gating for synchronization of energy delivery
  4. Test pulse for proximity detection to phrenic nerve
The PulseSelect™ pulsed field ablation system, with callouts highlighting the integrated proximity indicator display for real-time tissue contact assessment.

PulseSelect™ PFA system with PulseSelect ProxBox™ adapter and FlexCath Contour™ steerable sheath

The FlexCath Cross™ transseptal solution alongside the FlexCath Contour™ steerable sheath.

Seamless compatibility with transseptal access solutions

The PulseSelect™ system is designed for compatibility with the FlexCath Cross™ transseptal solution and FlexCath Contour™ steerable sheath. It supports access, easy movement, and flexible workflow.

FlexCath Cross™ transseptal solution

  • Enables a zero exchange workflow
  • Designed to streamline transseptal access
  • Supports efficient integration with the PulseSelect PFA system

FlexCath Contour™ steerable sheath

  • 10 Fr steerable sheath
  • Designed to provide maximum reach and enhanced maneuverability
  • Supports stable catheter positioning across a range of anatomies

Frequently asked questions

PFA designed for simplified adaptability

A plug-and-play PFA system with an integrated proximity indicator to complement existing contact assessment techniques.

  • Nine active electrodes support real-time contact feedback, EGM sensing, pacing, and catheter visualization
  • Visualization on existing mapping systems
  • Compatible with intracardiac echocardiography (ICE) and fluoroscopy only workflows.

Expand All

The PulseSelect™ PFA catheter is indicated for the treatment of drug refractory, recurrent, symptomatic paroxysmal atrial fibrillation (PAF) and persistent atrial fibrillation. In the PULSED AF pivotal trial, the PulseSelect™ PFA system demonstrated effectiveness in both patient populations.2

The PulseSelect™ PFA system was designed to provide electrophysiologists with a familiar, adaptable workflow for precise pulsed field energy delivery.

Key features include:

  • Over-the-wire loop catheter design for stability and self-centering control
  • Fixed electrode spacing to support predictable and consistent energy delivery
  • Nine active electrodes for real-time electrograms and catheter visualization
  • Compatibility with existing EP workflows, including use with any mapping system or fluoroscopy-only procedures
  • Fast energy delivery, with all pulmonary veins isolated in less than 30 seconds of total energy application during the PULSED AF trial2
  • Optional phrenic nerve test pulse to assess catheter proximity prior to energy delivery

The PULSED AF pivotal trial evaluated the PulseSelect™ PFA system in patients with paroxysmal and persistent AF. The study demonstrated effectiveness in both patient populations and a primary safety event rate of 0.7% in each cohort. Acute pulmonary vein isolation was achieved 100% of pulmonary veins treated (1,200/1,200 pulmonary veins).2

Yes. The PulseSelect™ PFA system was designed for seamless adaptability within the electrophysiology lab and can be used with any mapping system or with fluoroscopy-only workflows.

Ordering information

Item number Description
PSCC100 PulseSelect PFA catheter
PSG100 PulseSelect PFA generator

Resources

Related links

Watch live and on-demand webinars.

Watch physician-led webinars dedicated to the latest innovations shaping the future of cardiac ablation.

EP Insights Live (open in new window)

Educational resources on Medtronic Academy

Access detailed product information, including specification sheets, videos, and presentations.

Visit Medtronic Academy

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† Study design varies. All studies included a PVI approach using the PulseSelect™ PFA system with major complications reported. Four major complications reported in 1,572 patients (one tamponade, two stroke/TIA, one pericarditis).

‡ Three independent studies with various workflow, venous anatomies, and sedation strategies.

 
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  16. Goyal S, Bhimani A, Hoosien M. PVI Using the Pulse Select PFA System in Paroxysmal AF: One-Year Outcomes with Continuous Implantable Loop Recorder Monitoring. Poster presented at: AF Symposium 2026; February 5–7, 2026; Boston, MA. 
  17. Verma A, Molon G, Lacotte J, et al. The REAL PULSE Global Registry: Real-world acute efficacy and safety outcomes for the use of a circular multielectrode array pulsed field ablation system for atrial fibrillation treatment. Poster presented at: HRS 2026; April 24–26, 2026; Chicago, IL.