Superficial vein
<p>The VenaSeal™ closure system uses a proprietary medical adhesive to treat patients with superficial vein disease.</p>
UnitedHealthcare (UHC) has expanded its commercial coverage for venous disease treatments to include the VenaSeal™ closure system.
Effective July 1, 2025
Watch as Dr. Kathleen Gibson delivers immediate and lasting vein closure with our proprietary medical adhesive.1–5
View a VenaSeal™ closure system procedure animation to see how the single, double, and triple segment treatment options work.
Hear about Steve’s experience with the VenaSeal™ closure system.
Hear about Heather’s experience with the VenaSeal™ closure system.
The VenaSeal™ closure system procedure offers:
The VenaSeal™ closure system procedure eliminates2,4:
Adverse events can include allergic reaction, inflammation, phlebitis, deep vein thrombosis, and/or pulmonary embolism.
† Demonstrated in C2–C4 patients.
‡ Based on multi-center retrospective cohort study of 119 patients with CEAP class 6 venous ulcers.
§ Some patients may benefit from the use of compression stockings post-procedure.
Long-term evidence with high clinical standards
9 of 10
patients would choose VenaSeal™ procedure again at five years5
75%
improvement in VCSS scores at five years5
94.6%
closure rate at five years5
| VenaSeal™ adhesive | Five mL of the VenaSeal™ adhesive (a specially formulated n-butyl-2-cyanoacrylate) is contained within a screw-capped vial. |
|---|---|
Dispenser gun |
The dispenser gun consists of a pistol-type ergonomic handle with an integrated barrel and trigger. Each depression of the trigger delivers a controlled 0.10 mL (range: 0.06–0.12 mL) amount of adhesive. |
| Catheter | The catheter is 5 Fr with an effective length of 91 cm, laser markings at 3 cm and 85 cm from the tip, and high echogenic visibility. |
| Introducer | The introducer is 7 Fr with an effective length of 80 cm, with 10 mm spaced circumferential markings along its length for measuring retraction length during the VenaSeal™ procedure. |
| Dilator | The dilator is 5 Fr with an effective length of 87 cm. |
| Syringe | The 3 mL syringes are graduated Monoject™* luer-lock syringes, each with a standard threaded luer-lock connector. |
| Dispenser tips | The dispenser tips are each comprised of a stainless steel, 1.5 mm ID, 3.8 cm length hypotube with a luer-lock connector. |
| Guidewire | The guidewire is a 0.035 in, 180 cm straight floppy-tip guidewire. |
The VenaSeal™ closure system is a nonthermal, nontumescent treatment for superficial vein disease, specifically for the permanent closure of lower extremity superficial truncal veins like the great saphenous vein. It uses a medical adhesive to seal the diseased vein, rerouting blood to healthier veins. The adhesive polymerizes upon contact with blood, bonding with the vein’s intima, and is encapsulated by fibrotic tissue over time.1-4,7
The VenaSeal™ system has a demonstrated closure rate of 94.6% at five years, with 0 DVT (deep vein thrombosis), 0 PE (pulmonary embolism), and significant improvements in quality of life.5,6
The VenaSeal™ system offers advantages over thermal ablation, including no need for tumescent anesthesia, less pain and bruising, and faster recovery time. Thermal ablation uses heat, requiring multiple needle sticks for numbing medicine and compression stockings post-procedure.3,8
The VenaSeal™ system procedure is nonthermal, nonsclerosant vein closure using a proprietary cyanoacrylate adhesive. It uses a single local anesthetic injection with fewer needle punctures compared to foam sclerotherapy. Unlike with foam sclerotherapy, there is no routine need for post-procedure compression stockings after the VenaSeal™ system procedure.§
The VenaSeal™ system procedure demonstrated a one-year closure rate of 96.8%,¶,5 and a five-year closure rate of 94.6%.¶,5 Foam sclerotherapy one-year closure rate was 73%,¶,10 and no long-term outcomes have been reported. There were zero reported DVTs over five years with the VenaSeal™ system,1 and up to 8.6% DVT risk with foam sclerotherapy.11
The VenaSeal™-treated vein becomes permanently closed as the body creates scar tissue around the adhesive over time, ensuring the vessel remains sealed.7
Insurance coverage for the VenaSea™ system procedure varies by provider and plan. Some payers, including UnitedHealthcare and others listed in the VenaSeal™ closure system payer coverage list, provide coverage if medical necessity is documented. Providers should confirm coverage with the specific payer.
The VenaSeal™ system procedure is considered safe and effective for treating symptomatic venous reflux. However, it is contraindicated in patients with hypersensitivity to cyanoacrylates, acute superficial thrombophlebitis, thrombophlebitis migrans, or acute sepsis. Potential adverse effects include hypersensitivity reactions, deep vein thrombosis, pulmonary embolism, and others.1
The VenaSeal™ system procedure does not require compression stockings after the procedure, and repeated visits are generally not needed. However, some patients may benefit from compression stockings post-procedure.
| Item number | Description |
|---|---|
| VS-404 | Glass vial with 5 mL adhesive, dispenser gun, 5 Fr x 91 cm catheter, 7 Fr x 80 cm introducer, 5 Fr x 87 cm dilator, (2) 3 mL syringes, (2) 14 ga dispenser tips, guidewire: 0.035 in, (0.89 mm) 180 cm straight floppy-tip |
| Item number | Description |
|---|---|
| CFP | Procedure pack — scalpel, surgical marking pen, probe cover, table cover, plastic clamp towel, custom label, sharps block, skin closure strip, gowns, dry sponge sticks, bowls, drapes, table cover tapes, needles, and more |
| MIS-7F07 | Micro introducer sheath set — 7 Fr x 7 cm, 21 ga TW needle, guidewire: 0.018 in x 45 cm, single-ended: straight |
| MIS-7F11 | Micro introducer sheath set — 7 Fr x 11 cm, 21 ga TW needle, guidewire: 0.018 in x 45 cm, single-ended: straight |
| MIS-6F07 | Micro introducer sheath set — 6 Fr x 7 cm, 21 ga TW needle, guidewire: 0.018 in, 45 cm, single-ended: straight |
| MIS-6F11 | Micro introducer sheath set — 6 Fr x 11 cm, 21 ga x TW needle, guidewire: 0.018 in, 45 cm, single-ended: straight |
| IS-7F07 | Introducer sheath set — 7 Fr x 7 cm, 19 ga UTW needle, guidewire: 0.035 in x 45 cm, J / straight double-ended |
| IS-7F11 | Introducer sheath set — 7 Fr x 11 cm, 19 ga UTW needle, guidewire: 0.035 in x 45 cm, J / straight double-ended |
| MPK-5F | Micro puncture kit — 5 Fr, 21 ga TW needle, guidewire: 0.018 in x 45 cm, single-ended: straight |
| AN-19G | Percutaneous entry needle — 19 ga, length: 2.75 in, UTW |
| AN-19GE | Percutaneous entry needle — 19 ga, length: 2.75 in, UTW echogenic tip |
| GW-018-45-SS | Guidewire — diameter: 0.018 in, length: 45 cm, single-ended: straight, fixed core, PTFE coated |
| GW-035-45 | Guidewire — diameter: 0.035 in, length: 45 cm, double-ended: 3 mm J and straight, fixed core, PTFE coated |
| PC-6X96 | Ultrasound probe cover |
TM* Third-party brands are trademarks of their respective owners.
† Demonstrated in C2–C4 patients.
‡ Based on multi-center retrospective cohort study of 119 patients with CEAP class 6 venous ulcers.
§ Some patients may benefit from the use of compression stockings post-procedure.
¶ After a single treatment.
