Demineralized Bone Matrix

Follow the leader in DBMs.

Biologic grafts from Medtronic — including Grafton™ and Magnifuse™ grafts — are designed to work with the body’s natural healing processes. Derived from donor tissue, each graft provides a scaffold that supports bone growth and fusion.

Grafton™ has over
30 years

of processing history^† and has been used in over 1.5 million procedures worldwide.

Grafton™ DBM

Legacy of performance. Confidence you can trust.

High osteoinductive potential. Proprietary D-Min™ process preserves native growth factors to support bone formation.^†
Versatile formats. Available in injectable, fiber, and composite forms for procedural flexibility
Enhanced safety potential. Aseptic processing and viral inactivation ensure high safety standards.¹
Minimally-invasive delivery. Designed for easy delivery, packing, and retention at the graft site
Proven technology. Grafton™ DBM is the most utilized and scientifically studied DBM brand with over 160 publications²

Indications, Safety, and WarningsIndications for useCaution: GRAFTON™ DBM DBF is restricted to use by a physician, podiatrist, or dentist. GRAFTON™ DBM DBF can be used in orthopedic or reconstructive bone grafting procedures. The product can also be used in bone grafting procedures in combination with autologous bone or other forms of allograft bone, or alone as a bone graft. The contents of an individual GRAFTON™ DBM DBF container are intended for single patient use only. Do not use the contents of any container for multiple patients. Empty or partially used containers should be disposed of in accordance with recognized procedures for discarding medical waste materials. Preparation of the bone graft bed is important for graft incorporation and bone formation, as are other factors such as blood supply, source of marrow elements, loading, stability, and absence of infection at the graft site. The volume of graft material used in each procedure is determined by the judgment of the clinician.CautionThis allograft may contain trace amounts of antibiotics (gentamicin) and processing solutions. Caution should be exercised if the patient is allergic to these antibiotics or processing solutions.PrecautionsExtensive donor blood serum testing, medical and social history screening procedures, and tissue microbiological testing have been used in the qualification of all tissue donors. Despite the viral inactivation and extensive tissue donor selection and qualification processes used in providing this tissue graft, transmission of a communicable disease through the use of this tissue graft is still possible. Bacterial infection at the graft site may also occur. Any adverse outcomes potentially attributable to GRAFTON™ DBM DBF must be reported promptly to Medtronic.ContraindicationsThe presence of infection at the transplantation site is a contraindication for the use of this allograft.

Magnifuse™ bone graft

Advanced biologic. Streamlined delivery.

High osteoinductive potential. Engineered with a PGA mesh bag containment system and demineralized bone matrix to support bone growth and healing.^†
Integrated design. Combines DBM with a resorbable scaffold for optimal handling and site retention.
Efficient handling. Mesh-contained allograft for simplified application and reduced prep time.
Proven technology. Demonstrated efficacy across spinal fusion procedures in peer-reviewed studies.²

Indications, Safety, and WarningsIndicationsMagnifuse™ Bone Graft is intended for use as a bone graft substitute in bony voids or gaps of the skeletal system (i.e., spine, pelvis and extremities) not intrinsic to the stability of the bony structure. The voids or gaps may be surgically created defects or defects created by traumatic injury to the bone.Magnifuse™ Bone Graft may be used in a manner comparable to autogenous bone or allograft bone. Magnifuse™ Bone Graft may be mixed with fluid such as bone marrow aspirate, blood, sterile water, or sterile saline in order to adjust the consistency and handling characteristics of the bone graft material. Magnifuse™ Bone Graft is resorbed/remodeled and replaced by host bone during the healing process.Magnifuse™ II Bone Graft is intended for use as a bone graft substitute in bony voids or gaps of the skeletal system (i.e., posterolateral spine and pelvis) not intrinsic to the stability of the bony structure. The voids or gaps may be surgically created defects or defects created by traumatic injury to the bone. Magnifuse™ II Bone Graft is resorbed/remodeled and replaced by host bone during the healing process.ContraindicationsThe following are contraindications for the use of Magnifuse™ DBM Bone Graft and Magnifuse™ II Bone Graft:

The presence of infection at the transplantation site.

Treatment of spinal insufficiency fractures.

CautionThis product may contain trace amounts of antibiotics (gentamicin), surfactant, and other solutions used in processing the bone tissue as well as the PGA mesh. Caution should be exercised if the patient is allergic to these antibiotics or chemicals.PrecautionsExtensive donor blood serum testing, medical and social history screening procedures, and tissue microbiological testing have been used in the qualification of all tissue donors. Despite the viral inactivation and extensive tissue donor selection and qualifications process used in providing this tissue graft, transmission of an infectious disease through the use of this tissue graft is still possible. Bacterial infection at the graft site may also occur. Any adverse outcomes potentially attributable to Magnifuse™ or Magnifuse™ II Bone Graft must be reported promptly to Medtronic (i.e., spine, pelvis, and extremities). Adequate fixation should be used to stabilize the implant site during bone formation and healing in bony voids or gaps of the skeletal system.

† Data on file. Animal studies are not necessarily indicative of human clinical outcomes.

Demineralized bone matrix

Follow the leader in DBMs.

Grafton™ DBM

Legacy of performance. Confidence you can trust.

Magnifuse™ bone graft

Advanced biologic. Streamlined delivery.

United States

Customer Care Team