You just clicked a link to go to another website. If you continue, you may go to a site run by someone else.
It is possible that some of the products on the other site are not approved in your region or country.
Your browser is out of date
With an updated browser, you will have a better Medtronic website experience. Update my browser now.
The content of this website is exclusively reserved for Healthcare Professionals in countries with applicable health authority product registrations.
Click “OK” to confirm you are a Healthcare Professional.
Answering the most relevant
clinical questions in complex patients
Onyx ONE Global Trial results
Published by The New England Journal of Medicine
Onyx ONE Clear Analysis
Published by Circulation: Cardiovascular Interventions
Largest prospective study on left main (LM) PCI with a DES that has a dedicated extra-large stent platform (N = 450)
Low 5.1% TLF, 2.0% TLR, and 1.1% ST at one year5
First randomised trial based on European Bifurcation Club (EBC) consensus, comparing a provisional to a planned, dual-stent strategy, LM bifurcation PCI (N = 467)
Resolute Onyx™ DES demonstrated excellent outcomes at one year6
Single-arm prospective registry studying Resolute Onyx™ DES in small-vessel PCI (N = 302)
Complex patient population
0% stent thrombosis and low rate of CD-TLR at one year8
Resolute Onyx™ DES was safe and effective in complex, small coronary vessels.8
Third-party brands are trademarks of their respective owners.
Resolute Onyx DES received CE mark approval for 1-month DAPT in HBR patients in 2020.
Windecker S, Latib A, Kedhi E, et al. Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk. N Engl J Med. March 26, 2020;382(13):1208-1218.
Windecker S, et al. Final Two-Year Results from the Randomized Onyx ONE Trial in High Bleeding Risk Patients Treated with 1-month DAPT. Presented at ACC 2021.
Kandzari DE, Kirtane AJ, Windecker S, et al. One-Month Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Zotarolimus-Eluting Stents in High-Bleeding-Risk Patients. Circ Cardiovasc Interv. November 2020;13(11):e009565.
Resolute Onyx DES IFU M981345A001 Rev. AA..
Tarantini G, et al. The ROLEX Registry (Revascularization Of LEft Main With Resolute onyX). Presented at PCR 2022. Investigator-initiated study funded by Medtronic.
Hildick-Smith D, Egred M, Banning A, et al. The European bifurcation club Left Main Coronary Stent study: a randomized comparison of stepwise provisional vs. systematic dual stenting strategies (EBC MAIN). Eur Heart J. October 1, 2021;42(37):3829-3839.
Based on bench test data on file at Medtronic (method 10036340DOC). May not be indicative of clinical performance. Minimum of N=10 of each DES tested: Resolute Onyx DES, Orsiro DES, XIENCE Alpine™* DES, SYNERGY™* DES, Ultimaster™* DES.
Cuellas C, et al. Use of a Zotarolimus-eluting stent for small vessel disease (DISCO 9 Study). Presented at PCR 2021.
Von Birgelen C, Zocca P, Buiten RA, et al. Thin composite wire strut, durable polymer-coated (Resolute Onyx) versus ultrathin cobalt-chromium strut, bioresorbable polymer-coated (Orsiro) drug-eluting stents in allcomers with coronary artery disease (BIONYX): an international, single-blind, randomised non-inferiority trial. Lancet. October 6, 2018;392(10154):1235-1245.
See the device manual for detailed information regarding the instructions for use, the implant procedure, indications, contraindications, warnings, precautions, and potential adverse events. For further information, contact your local Medtronic representative and/or consult the Medtronic website at cema.medtronic.com.
For applicable products, consult instructions for use on www.medtronic.com/manuals. Manuals can be viewed using a current version of any major internet browser. For best results, use Adobe Acrobat® Reader with the browser.
Important Reminder: this information is intended only for users in markets where Medtronic products and therapies are approved or available for use as indicated within the respective product manuals. Content on specific Medtronic products and therapies is not intended for users in markets that do not have authorization for use.