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Arctic Front Advance™ Cryoballoon has demonstrated consistent outcomes among various centers.
Arrhythmia monitoring methods and definition of procedure success
(Freedom from AF Only or AF/AT/AFL) varied between studies.
Among centers with varying annual ablation volume, Arctic Front Advance Cryoballoon resulted in more consistent outcomes compared to radiofrequency.
* Standard deviations were smaller in the cryoballoon group for all three procedure time measures, indicating more consistent times with less variation from the mean.
** Protocol required 30 min. waiting period after last application to assess PV isolation.
Di Giovanni, et al. One-Year Follow-Up After Single Procedure Cryoballoon Ablation: A Comparison Between the First and Second Generation Balloon. J Cardiovasc Electrophysiol. 2014; 25(8):834-9.
Fürnkranz, et al. Improved 1-Year Clinical Success Rate of Pulmonary Vein Isolation with the Second-Generation Cryoballoon in Patients with Paroxysmal Atrial Fibrillation. J Cardiovasc Electrophysiol. 2014; 25(8):840-4
Aryana, et al. Acute procedural and cryoballoon characteristics from cryoablation of atrial fibrillation using the first- and second-generation cryoballoon: a retrospective comparative study with follow-up outcomes. J Interv Card Electrophysiol. 2014;41(2):177-86.
Aytemir, et al. Safety and efficacy outcomes in patients undergoing pulmonary vein isolation with second-generation cryoballoon. Europace. 2015; 17(3):379-87.
Greiss, et al. The impact of left atrial surface area and the second generation cryoballoon on clinical outcome of atrial fibrillation cryoablation. Pacing Clin Electrophysiol. 2015; 38(7):815-24.
Metzner, et al. One-Year Clinical Outcome After Pulmonary Vein Isolation Using the Second-Generation 28-mm Cryoballoon. Circ Arrhythm Electrophysiol. 2014;7(2):288-292.
Chierchia, et al. Second-generation cryoballoon ablation for paroxysmal atrial fibrillation: 1-year follow-up. Europace. 2014;16(5):639-644.
Chierchia, et al. Impact on Clinical Outcome of Premature Interruption of Cryoenergy Delivery Due to Phrenic Nerve Palsy During Second Generation Cryoballoon Ablation for Paroxysmal Atrial Fibrillation. Journal of Cardiovascular Electrophysiology. September 2015; 26:950-955.
Kumar, et al. Adenosine testing after second-generation balloon devices (cryothermal and laser) mediated pulmonary vein ablation for atrial fibrillation. J Interv Card Electrophysiol. 2014; 41(1):91-97.
Jourda, et al. Contact-force guided radiofrequency vs. second-generation balloon cryotherapy for pulmonary vein isolation in patients with paroxysmal atrial fibrillation-a prospective evaluation. Europace. 2015; 17(2):225-31.
Ciconte, et al. Single 3-minute freeze for second-generation cryoballoon ablation: one-year follow-up after pulmonary vein isolation. Heart Rhythm. 2015; 12(4):673-80.
Tebbenjohanns, et al. Shortening of freezing cycles provides equal outcome to standard ablation procedure using second-generation 28 mm cryoballoon after 15-month follow-up. Europace. 2016; 18(2):206-10.
Wissner, et al. One-year clinical success of a 'no-bonus' freeze protocol using the second-generation 28 mm cryoballoon for pulmonary vein isolation. Europace. 2015; 17(8):1236-40.
Providencia, et al. Cryoballoon or radiofrequency ablation for atrial fibrillation. New England Journal of Medicine. 2016; 375(11):1099.
Kuck, et al. Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation. N Engl J Med. 2016; 374(23): 2235-45.