Benefits and risks

The Medtronic Symplicity blood pressure procedure helps reduce high blood pressure (hypertension),1–3 which is shown to lower your risk of heart attacks, strokes, and other serious health problems.4


Illustration of a patient lying in a hospital bed while hooked up to an ECG with a female physician standing nearby


Reducing hypertension can lower some of your health risks.

Reducing blood pressure by 10 mmHg can lower your risk of:

heart failure4


cardiovascular events4





Illustrated pink and white pill in a left hand and a cup of water in a right hand

Beyond another daily blood pressure pill

While it may not affect how many medications you take, the Symplicity blood pressure procedure helps reduce high blood pressure without adding another pill to your daily regimen.1,2

Treatment beyond blood pressure medications

The Symplicity blood pressure procedure is proven to safely help lower blood pressure in people who are taking blood pressure medication and those who are not.1,2



blood pressure reduction in a three-year study of people who received the Symplicity procedure3


What are the risks of the Symplicity blood pressure procedure?

The Medtronic Symplicity blood pressure procedure, just like any medical procedure, has risks. It's important to talk with your doctor about the benefits and risks. 

The potential risks as well as complication rates for the Symplicity blood pressure procedure are similar to those associated with other interventional procedures.

See how it works.

Get more details about the Symplicity blood pressure procedure.



Kandzari et al. Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications. Journal of the American College of Cardiology. 2023;82(19):1809–1823.


Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. May 2, 2020;395(10234):1444–1451.


Mahfoud F, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of the Global SYMPLICITY Registry DEFINE. Presented at euroPCR 2023. Includes Symplicity Spyral™ and Flex catheters.


Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and metaanalysis. Lancet. March 5, 2016;387(10022):957–967.