Clinical evidence and patient stories

The Symplicity blood pressure procedure is a single, minimally invasive procedure that is proven to be safe and effective in helping to lower blood pressure.1–3


Illustration of a doctor standing in front of a man and a woman


Clinical evidence

See what success looks like.

Adverse events include, but are not limited to, bruising and pain. Results may vary.

Decorative element

In a three-year study of people taking their prescribed blood pressure medications, the procedure helped reduce blood pressure by 16.7 mmHg.3

Decorative element

More than 25,000 people worldwide have received this procedure.4

Patient stories

Listen to real-life stories.

Ferruccio, Kasim, and Joseph talk about how the Symplicity blood pressure procedure made a difference in their lives.

These are individual experiences. Their thoughts and opinions are their own. Not everyone will experience the same results.

Hear from a doctor.

Dr. Andrew Sharp explains how the Symplicity blood pressure procedure has helped his patients reduce their blood pressure.



Kandzari et al. Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications. Journal of the American College of Cardiology. 2023;82(19):1809–1823.


Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. May 2, 2020;395(10234):1444–1451.


Mahfoud F, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of Global SYMPLICITY Registry DEFINE. Presented at euroPCR 2023. Includes Syplicity Spyral™ and Flex catheters.


Medtronic data on file. Includes Symplicity Spyral™ and Flex catheters.